Evidence map›Paper›PMID 38518777›Full record

ArticleCurrent biology : CB2024

A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding.

Pablo B Martinez de Morentin, J Antonio Gonzalez, Georgina K C Dowsett, Yuliia Martynova, Giles S H Yeo, Sergiy Sylantyev, Lora K Heisler

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
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  4. Vagal GABAergic signaling in autonomic control of cardiometabolic function.American journal of physiology. Cell physiology · 2026
    Review
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  9. The Genetic Blueprint of Obesity: From Pathogenesis to Novel Therapies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
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  13. Article
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  17. The role of GIPR in food intake control.Frontiers in endocrinology · 2025
    Review
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  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Pablo B Martinez de MorentinThe Rowett Institute, University of Aberdeen, Ashgrove Road W, Aberdeen AB25 2ZD, UK; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Woodhouse LS2 9JT, UK. Electronic address: p.demorentin@leeds.ac.uk.
J Antonio GonzalezThe Rowett Institute, University of Aberdeen, Ashgrove Road W, Aberdeen AB25 2ZD, UK.
Georgina K C DowsettMRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Yuliia MartynovaThe Rowett Institute, University of Aberdeen, Ashgrove Road W, Aberdeen AB25 2ZD, UK.
Giles S H YeoMRC Metabolic Diseases Unit, Institute of Metabolic Science, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
Sergiy SylantyevThe Rowett Institute, University of Aberdeen, Ashgrove Road W, Aberdeen AB25 2ZD, UK; Odesa National Mechnikov University, Biological Department, 2 Shampansky Ln., Odesa 65015, Ukraine. Electronic address: s.sylantyev@abdn.ac.uk.
Lora K HeislerThe Rowett Institute, University of Aberdeen, Ashgrove Road W, Aberdeen AB25 2ZD, UK.
University of Aberdeen · GBUniversity of Cambridge · GBUniversity of Leeds · GB

Funding

Medical Research Council MC_UU_00014/1Wellcome Trust
6 · The paper itself

Abstract

The obesity epidemic is principally driven by the consumption of more calories than the body requires. It is therefore essential that the mechanisms underpinning feeding behavior are defined. Neurons within the brainstem dorsal vagal complex (DVC) receive direct information from the digestive system and project to second-order regions in the brain to regulate food intake. Although γ-aminobutyric acid is expressed in the DVC (GABA

Indexed as

Arcuate Nucleus of HypothalamusBrain StemFeeding BehaviorAnimalsEatingFemaleGABAergic Neuronsgamma-Aminobutyric AcidMaleMiceMice, Inbred C57BLgamma-Aminobutyric Acidbody weightdorsal vagal complexfood intakegamma-aminobutyric acidhungerhypothalamusneuropeptide Ynucleus of the solitary tractobesity

Identifiers

PMID38518777
PMCPMC7617324
OpenAlexW4393038303

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.