Evidence map›Paper›PMID 38518516›Full record

ArticleAtherosclerosis2024

Multifaceted roles of Meg3 in cellular senescence and atherosclerosis.

Xiao Cheng, Mohamed Sham Shihabudeen Haider Ali, Vijaya Bhaskar Baki, Matthew Moran, Huabo Su, Xinghui Sun

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiao ChengDepartment of Biochemistry, University of Nebraska - Lincoln, Beadle Center, 1901 Vine St, Lincoln, NE, 68588, USA.
Mohamed Sham Shihabudeen Haider AliDepartment of Biochemistry, University of Nebraska - Lincoln, Beadle Center, 1901 Vine St, Lincoln, NE, 68588, USA.
Vijaya Bhaskar BakiDepartment of Biochemistry, University of Nebraska - Lincoln, Beadle Center, 1901 Vine St, Lincoln, NE, 68588, USA.
Matthew MoranDepartment of Biochemistry, University of Nebraska - Lincoln, Beadle Center, 1901 Vine St, Lincoln, NE, 68588, USA.
Huabo SuVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA; Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Xinghui SunDepartment of Biochemistry, University of Nebraska - Lincoln, Beadle Center, 1901 Vine St, Lincoln, NE, 68588, USA; Nebraska Center for the Prevention of Obesity Diseases Through Dietary Molecules, University of Nebraska - Lincoln, USA. Electronic address: xsun17@unl.edu.
University of Nebraska–Lincoln · USAugusta University · US

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0M
The role of stress in the fetal origin of obesity and metabolic dysfunctionP20GM104320 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI ZEMPLENI, JANOS · 2014 to 2024
$24.9M
Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI GUO, JIANTAO · 2016 to 2025
$20.8M
Neddylation and cardiac protein quality controlR01HL124248 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2014 to 2024
$4.1M
Mitochondrial quality control in the heartR01HL165205 · NHLBI · AUGUSTA UNIVERSITY · PI SU, HUABO · 2022 to 2025
$2.4M
Elucidating the role of Cullin 3 in the heartR01HL173796 · NHLBI · AUGUSTA UNIVERSITY · PI Huabo Su · 2024 to 2026
$2.0M
Role of lncRNA Meg3 in obesity-induced endothelial senescence and insulin resistanceR01HL150536 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI SUN, XINGHUI · 2020 to 2023
$2.0M
NHLBI NIH HHS R01 HL124248NHLBI NIH HHS R01 HL150536NHLBI NIH HHS R01 HL165205NHLBI NIH HHS R01 HL173796NIDDK NIH HHS P30 DK046200NIGMS NIH HHS P20 GM104320NIGMS NIH HHS P20 GM113126
6 · The paper itself

Abstract

BACKGROUND AND

aimsLong noncoding RNAs are involved in the pathogenesis of atherosclerosis. As long noncoding RNAs maternally expressed gene 3 (Meg3) prevents cellular senescence of hepatic vascular endothelium and obesity-induced insulin resistance, we decided to examine its role in cellular senescence and atherosclerosis. METHODS AND

resultsBy analyzing our data and human and mouse data from the Gene Expression Omnibus database, we found that Meg3 expression was reduced in humans and mice with cardiovascular disease, indicating its potential role in atherosclerosis. In Ldlr

conclusionsOur data demonstrate that Meg3 promotes the formation of atherosclerotic lesions independent of its effects on plasma lipid profiles. In addition, Meg3 regulates cellular senescence in a tissue-specific manner during atherosclerosis. Thus, we demonstrated that Meg3 has multifaceted roles in cellular senescence and atherosclerosis.

Indexed as

AtherosclerosisCellular SenescenceRNA, Long NoncodingAnimalsAortic DiseasesCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Disease Models, AnimalFemaleHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21MEG3 non-coding RNA, humanMEG3 non-coding RNA, mousePCSK9 protein, humanPcsk9 protein, mouseProprotein Convertase 9Receptors, LDLRNA, Long NoncodingAtherosclerosisCellular senescenceLong noncoding RNAsMeg3Vascular endothelium

Identifiers

PMID38518516
PMCPMC11088985
OpenAlexW4392582391

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.