Evidence map›Paper›PMID 38518513›Full record

ArticleJournal of the mechanical behavior of biomedical materials2024

Evaluation of gelatin bloom strength on gelatin methacryloyl hydrogel properties.

Samantha G Zambuto, Samyuktha S Kolluru, Eya Ferchichi, Hannah F Rudewick, Daniella M Fodera, Kristin M Myers, Silviya P Zustiak, Michelle L Oyen

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the mechanical behavior of biomedical materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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  4. Fiber-Reinforced Composites for Vaginal Tissue Engineering Applications.Journal of biomedical materials research. Part A · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Samantha G ZambutoDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, 63130, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA; Center for Women's Health Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Samyuktha S KolluruCenter for Women's Health Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA; The Institute of Materials Science & Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA.
Eya FerchichiDepartment of Biomedical Engineering, Saint Louis University, St. Louis, MO, 63103, USA.
Hannah F RudewickDepartment of Chemical Engineering, Texas A&M University, College Station, TX, 77843, USA.
Daniella M FoderaDepartment of Biomedical Engineering, Columbia University, New York, NY, USA.
Kristin M MyersDepartment of Mechanical Engineering, Columbia University, New York, NY, USA.
Silviya P ZustiakDepartment of Biomedical Engineering, Saint Louis University, St. Louis, MO, 63103, USA.
Michelle L OyenDepartment of Obstetrics and Gynecology, Washington University School of Medicine, St. Louis, MO, 63130, USA; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA; Center for Women's Health Engineering, Washington University in St. Louis, St. Louis, MO, 63130, USA. Electronic address: oyen@wustl.edu.
Washington University in St. Louis · USColumbia University · USSaint Louis University · USTexas A&M University · US

Funding

Clinical Outcomes Research Training in Female Lower Urinary Tract DisordersT32DK120497 · NIDDK · WASHINGTON UNIVERSITY · PI LOWDER, JERRY LANE, SUTCLIFFE, SIOBHAN · 2020 to 2024
$879k
NIDDK NIH HHS T32 DK120497
6 · The paper itself

Abstract

Gelatin methacryloyl (GelMA) hydrogels are widely used for a variety of tissue engineering applications. The properties of gelatin can affect the mechanical properties of gelatin gels; however, the role of gelatin properties such as bloom strength on GelMA hydrogels has not yet been explored. Bloom strength is a food industry standard for describing the quality of gelatin, where higher bloom strength is associated with higher gelatin molecular weight. Here, we evaluate the role of bloom strength on GelMA hydrogel mechanical properties. We determined that both bloom strength of gelatin and weight percent of GelMA influenced both stiffness and viscoelastic ratio; however, only bloom strength affected diffusivity, permeability, and pore size. With this library of GelMA hydrogels of varying properties, we then encapsulated Swan71 trophoblast spheroids in these hydrogel variants to assess how bloom strength affects trophoblast spheroid morphology. Overall, we observed a decreasing trend of spheroid area and Feret diameter as bloom strength increased. In identifying clear relationships between bloom strength, hydrogel mechanical properties, and trophoblast spheroid morphology, we demonstrate that bloom strength should considered when designing tissue engineered constructs.

Indexed as

GelatinTissue ScaffoldsHydrogelsMethacrylatesTissue EngineeringGelatingelatin methacryloylHydrogelsMethacrylatesBloom strengthGelatinGelatin methacryloylHydrogel propertiesMicroindentationTrophoblast spheroids

Identifiers

PMID38518513
PMCPMC12662645
OpenAlexW4392921805

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.