Evidence map›Paper›PMID 38518503›Full record

ArticlePediatric neurology2024

Genetic and Congenital Anomalies in Infants With Hypoxic-Ischemic Encephalopathy.

Adriana S Morell, Sarah E Monsell, Marie-Coralie Cornet, Jessica L Wisnowski, Robert C McKinstry, Amit M Mathur, Yi Li, Hannah C Glass, Fernando F Gonzalez, Dennis E Mayock and 19 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Racial disparities and outcomes in neonatal hypoxic-ischemic encephalopathy.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors at 18 institutions in 1 country.

Adriana S MorellDepartment of Neurology, University of California San Francisco, San Francisco, California. Electronic address: adriana.morell@ucsf.edu.
Sarah E MonsellDepartment of Biostatistics, University of Washington, Seattle, Washington.
Marie-Coralie CornetDepartment of Pediatrics, University of California San Francisco, San Francisco, California.
Jessica L WisnowskiDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California; Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California.
Robert C McKinstryDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri.
Amit M MathurDepartment of Pediatrics, Saint Louis University School of Medicine, St. Louis, Missouri.
Yi LiDepartment of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California.
Hannah C GlassDepartment of Neurology, University of California San Francisco, San Francisco, California; Department of Pediatrics, University of California San Francisco, San Francisco, California; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Fernando F GonzalezDepartment of Pediatrics, University of California San Francisco, San Francisco, California.
Dennis E MayockDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
Kristen L BenningerDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio.
Krisa P Van MeursDepartment of Pediatrics, Stanford University School of Medicine, Stanford, California.
Andrea L LamplandDepartment of Neonatology, Children's Minnesota, St. Paul, Minnesota.
Tai-Wei WuDepartment of Pediatrics, Children's Hospital Los Angeles, Los Angeles, California; Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, California.
David RileyDepartment of Pediatrics, Cook Children's Medical Center, Ft. Worth, Texas; Department of Pediatrics, Texas Christian University, Ft. Worth, Texas; Department of Pediatrics, University of North Texas Health Science Center, Ft. Worth, Texas.
Ulrike MietzschDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
Lina ChalakDepartment of Pediatrics, The University of Texas Southwestern Medical Center, Dallas, Texas.
John FlibotteDepartment of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.
Joern-Hendrick WeitkampDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Kaashif A AhmadPediatrix Medical Group of San Antonio, San Antonio, Texas; Department of Pediatrics, Children's Hospital of San Antonio, San Antonio, Texas; Department of Pediatrics, Methodist Children's Hospital, San Antonio, Texas.
Toby D YanowitzDepartment of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania; Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, Pennsylvania; Department of Pediatrics, Magee Women's Hospital of UPMC, Pittsburgh, Pennsylvania.
Mariana BasergaDepartment of Pediatrics, University of Utah, Salt Lake City, Utah.
Stephanie MerharDepartment of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Rakesh RaoDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.
Gregory M SokolDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana.
Bryan A ComstockDepartment of Biostatistics, University of Washington, Seattle, Washington.
Patrick J HeagertyDepartment of Biostatistics, University of Washington, Seattle, Washington.
Sandra E JuulDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington.
Yvonne W WuDepartment of Neurology, University of California San Francisco, San Francisco, California; Department of Pediatrics, University of California San Francisco, San Francisco, California.
University of California, San Francisco · USUniversity of Washington · USWashington University in St. Louis · USChildren's Hospital of Los Angeles · USChildren's Hospital of Philadelphia · USChildren's Hospital of San Antonio · USChildren’s Minnesota - St. Paul Hospital · USCincinnati Children's Hospital Medical Center · USIndiana University School of MedicineNationwide Children's Hospital · USSaint Louis University · USStanford University · USThe University of Texas Southwestern Medical Center · USUniversity of North Texas · USUniversity of Pittsburgh · USUniversity of Southern California · USUniversity of Utah · USVanderbilt University Medical Center · US

Funding

High-dose Erythropoietin for Asphyxia and Encephalopathy (HEAL) CCCU01NS092764 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JUUL, SANDRA E, WU, YVONNE W · 2016 to 2020
$12.7M
Enhanced cellular therapy for neonatal strokeR01NS107039 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Fernando Francisco Gonzalez · 2018 to 2026
$3.8M
Validating MRS lipids as biomarkers of brain injury in neonates with hypoxic-ischemic encephalopathyK23HD099309 · NICHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI WISNOWSKI, JESSICA L · 2019 to 2023
$693k
NICHD NIH HHS K23 HD099309NINDS NIH HHS R01 NS107039NINDS NIH HHS U01 NS092764
6 · The paper itself

Abstract

backgroundInfants with hypoxic ischemic encephalopathy (HIE) may have underlying conditions predisposing them to hypoxic-ischemic injury during labor and delivery. It is unclear how genetic and congenital anomalies impact outcomes of HIE.

methodsInfants with HIE enrolled in a phase III trial underwent genetic testing when clinically indicated. Infants with known genetic or congenital anomalies were excluded. The primary outcome, i.e., death or neurodevelopmental impairment (NDI), was determined at age two years by a standardized neurological examination, Bayley Scales of Infant Development, Third Edition (BSID-III), and the Gross Motor Function Classification Scales. Secondary outcomes included cerebral palsy and BSID-III motor, cognitive, and language scores at age two years.

resultsOf 500 infants with HIE, 24 (5%, 95% confidence interval 3% to 7%) were diagnosed with a genetic (n = 15) or congenital (n = 14) anomaly. Infants with and without genetic or congenital anomalies had similar rates of severe encephalopathy and findings on brain magnetic resonance imaging. However, infants with genetic or congenital anomalies were more likely to have death or NDI (75% vs 50%, P = 0.02). Among survivors, those with a genetic or congenital anomaly were more likely to be diagnosed with cerebral palsy (32% vs 13%, P = 0.02), and had lower BSID-III scores in all three domains than HIE survivors without such anomalies.

conclusionsAmong infants with HIE, 5% were diagnosed with a genetic or congenital anomaly. Despite similar clinical markers of HIE severity, infants with HIE and a genetic or congenital anomaly had worse neurodevelopmental outcomes than infants with HIE alone.

Indexed as

Cerebral PalsyHypothermia, InducedHypoxia-Ischemia, BrainBrainChildChild, PreschoolHumansInfantMagnetic Resonance ImagingCongenital anomalyGenetic anomalyHypoxic-ischemic encephalopathyNeonatal

Identifiers

PMID38518503
PMCPMC12227132
OpenAlexW4391953076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.