Evidence map›Paper›PMID 38518375›Full record

ArticleACS applied materials & interfaces2024

Harnessing RNA Technology to Advance Therapeutic Vaccine Antigens against Chagas Disease.

Chiara Mancino, Jeroen Pollet, Assaf Zinger, Kathryn M Jones, Maria José Villar, Ana Carolina Leao, Rakesh Adhikari, Leroy Versteeg, Rakhi Tyagi Kundu, Ulrich Strych and 5 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Chagas disease: host responses, parasite evasion and vaccine advances.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. The time has come for a vaccine against Chagas disease.Lancet regional health. Americas · 2025
    Review
  8. Nasal vaccination againstFrontiers in immunology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 6 countries.

Chiara MancinoCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.
Jeroen PolletDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Assaf ZingerCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.ORCID 0000-0001-7894-486X
Kathryn M JonesDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.ORCID 0000-0001-8745-1987
Maria José VillarDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Ana Carolina LeaoDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Rakesh AdhikariDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Leroy VersteegDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Rakhi Tyagi KunduDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Ulrich StrychDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Federica GiordanoCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.
Peter J HotezDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Maria Elena BottazziDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Francesca TaraballiCenter for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.ORCID 0000-0002-4959-1169
Cristina PovedaDepartment of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas 77030, United States.
Baylor College of Medicine · USHouston Methodist · USBaylor University · US

Funding

Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Suzanne AW Fuqua · 2007 to 2026
$73.9M
Virology CoreP30AI036211 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 1994 to 2015
$21.7M
BD Biosciences Special Order LSRIIS10RR024574 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI LUMPKIN, ELLEN A · 2009 to 2009
$430k
NCI NIH HHS P30 CA125123NCRR NIH HHS S10 RR024574NIAID NIH HHS P30 AI036211
6 · The paper itself

Abstract

Chagas disease (CD) (American trypanosomiasis caused by

Indexed as

Chagas DiseaseProtozoan VaccinesAnimalsAntigens, ProtozoanMiceRNARNA, MessengerTechnologyTissue DistributionAntigens, ProtozoanProtozoan VaccinesRNARNA, MessengerbiodistributionChagas diseaseimmunogenicitylipid nanoparticlesmRNA vaccine

Identifiers

PMID38518375
PMCPMC10996878
OpenAlexW4393074590

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.