Evidence map›Paper›PMID 38518102›Full record

ArticleBlood2024

Endothelial ZIP8 plays a minor role in BMP6 regulation by iron in mice.

Allison L Fisher, Sydney Phillips, Chia-Yu Wang, Joao A Paulo, Xia Xiao, Gillian A Moschetta, Adhvaith Sridhar, Joseph D Mancias, Jodie L Babitt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Overlaps in mammalian iron and manganese homeostasis: recent advances.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Allison L FisherNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-9393-2442
Sydney PhillipsNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0009-0002-3079-5978
Chia-Yu WangNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-3679-6453
Joao A PauloDepartment of Cell Biology, Harvard Medical School, Boston, MA.ORCID 0000-0002-4291-413X
Xia XiaoNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-9874-5240
Gillian A MoschettaNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Adhvaith SridharNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Joseph D ManciasDivision of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
Jodie L BabittNephrology Division and Endocrine Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Harvard University · US

Funding

TRAINING IN CELL STRUCTURE AND FUNCTION IN NEPHROLOGYT32DK007540 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS, SOBERMAN, ROY · 1986 to 2021
$7.2M
Regulation of Iron Homeostasis by BMP SignalingR01DK087727 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BABITT, JODIE L · 2010 to 2024
$6.0M
BMP Ligands in Hepcidin RegulationR01DK128068 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BABITT, JODIE L, CHRISTIAN, JAN L · 2021 to 2024
$2.6M
The role of NCOA4-mediated ferritinophagy in iron homeostasis and ferroptosisR01DK124384 · NIDDK · DANA-FARBER CANCER INST · PI MANCIAS, JOSEPH D · 2020 to 2024
$1.8M
NIDDK NIH HHS R01 DK087727NIDDK NIH HHS R01 DK124384NIDDK NIH HHS R01 DK128068NIDDK NIH HHS T32 DK007540
6 · The paper itself

Abstract

abstractIron-mediated induction of bone morphogenetic protein (BMP)6 expression by liver endothelial cells is essential for iron homeostasis regulation. We used multiple dietary and genetic mouse cohorts to demonstrate a minor functional role for the metal-ion transporter ZIP8 in regulating BMP6 expression under high-iron conditions.

Indexed as

Bone Morphogenetic Protein 6Cation Transport ProteinsIronAnimalsEndothelial CellsGene Expression RegulationHomeostasisLiverMiceMice, Inbred C57BLMice, KnockoutBmp6 protein, mouseBone Morphogenetic Protein 6Cation Transport ProteinsIronSlc39a8 protein, mouse

Identifiers

PMID38518102
PMCPMC11443574
OpenAlexW4393066354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.