ArticleScience advances2024
Complementary integration of organic electrochemical transistors for front-end amplifier circuits of flexible neural implants.
Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Monolithic 3D-Integrated All-Solid Ion-Gated Carbon Nanotube Transistors With Tunable Ionic Conductance for Multi-Timescale Reservoir Computing.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Organic Electrochemical Transistors for Neuromorphic Bioelectronics: Materials and Manufacturing Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Damage-Free Passivation of Ambipolar OECTs with Fluoropolymer Film for Enhanced Performance and Stability Toward Reliable Biosignal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-gain and broadband in vivo amplifiers enabled by matched materials.Nature communications · 2026Article
- Active devices and systems for closed-loop neuromodulation.Microsystems & nanoengineering · 2026Review
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Multi-scale imaging and recording of in-vivo neural activity.BMB reports · 2026Review
- Organic Electrochemical Transistors for Neuromorphic Devices and Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Emerging Implantable Sensor Technologies at the Intersection of Engineering and Brain Science.Biosensors · 2025Review
- Addressing transconductance-bandwidth trade-off by three-dimensional electrolyte-surrounded organic electrochemical transistors.Science advances · 2025Article
- An Implantable, Ultralow Distortion Bioelectronic Interface Integrating Light-Emitting Diodes and Graphene Field-Effect Transistors.ACS nano · 2025Article
- Single organic electrochemical neuron capable of anticoincidence detection.Science advances · 2025Article
- Organic Bioelectronics in Microphysiological Systems: Bridging the Gap Between Biological Systems and Electronic Technologies.Biosensors · 2025Review
- Contorted acene ribbons for stable and ultrasensitive neural probes.Science advances · 2025Article
- Additive Manufacturing of Organic Electrochemical Transistors: Methods, Device Architectures, and Emerging Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Bio-inspired electronics: Soft, biohybrid, and "living" neural interfaces.Nature communications · 2025Review
- Full Conjugation in a Polymer with Non-conjugated Piperazine-2,5-dione Units via Energy-minimized Lactam-to-Lactim Tautomerization Enables Water-gated Transistor Fluoride Sensors.Angewandte Chemie (International ed. in English) · 2025Article
- Spatial control of doping in conducting polymers enables complementary, conformable, implantable internal ion-gated organic electrochemical transistors.Nature communications · 2025Article
- Single ambipolar OECT-based inverter with volatility and nonvolatility on demand.Science advances · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to amplify, translate, and process small ionic potential fluctuations of neural processes directly at the recording site is essential to improve the performance of neural implants. Organic front-end analog electronics are ideal for this application, allowing for minimally invasive amplifiers owing to their tissue-like mechanical properties. Here, we demonstrate fully organic complementary circuits by pairing depletion- and enhancement-mode p- and n-type organic electrochemical transistors (OECTs). With precise geometry tuning and a vertical device architecture, we achieve overlapping output characteristics and integrate them into amplifiers with single neuronal dimensions (20 micrometers). Amplifiers with combined p- and n-OECTs result in voltage-to-voltage amplification with a gain of >30 decibels. We also leverage depletion and enhancement-mode p-OECTs with matching characteristics to demonstrate a differential recording capability with high common mode rejection rate (>60 decibels). Integrating OECT-based front-end amplifiers into a flexible shank form factor enables single-neuron recording in the mouse cortex with on-site filtering and amplification.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.