ArticleScience immunology2024
Intestinal tuft cell immune privilege enables norovirus persistence.
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
6.6field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 17 citations in OpenAlex.
- Implications of RNA virus persistence for post-acute sequelae and chronic inflammatory syndromes.Nature immunology · 2026Review
- IgA is necessary and sufficient to prevent norovirus infection in mice.Science translational medicine · 2026Article
- Eosinophil-epithelial interactions mediate protective intestinal remodeling during food allergy.bioRxiv : the preprint server for biology · 2026Article
- Gastrointestinal tuft cells: Recent insights and next questions.Science immunology · 2026Review
- XIAP Deficiency Impairs Colonic Tuft Cell Development and Predisposes to Crohn's Disease.MedComm · 2026Article
- Gut T cell-microbiota crosstalk orchestrates antibacterial immunity and mucosal homeostasis in teleost.Microbiome · 2026Article
- Dysregulated expression of the tumor suppressor p14ARF in cancer provides an effective target for TCR-T cell therapeutics.Journal for immunotherapy of cancer · 2026Article
- Mechanisms of Norovirus Immunity: Implications for Vaccine Design.Annual review of pathology · 2026Review
- The gut virome and regulatory T cell axis in health and systemic disease.Microbiome research reports · 2026Review
- TRIM47 inhibits murine norovirus replication in a strain-dependent manner.Journal of virology · 2025Article
- Protective or pathogenic? Tuft cells shape divergent immune outcomes in helminth and viral infections.Current opinion in immunology · 2025Review
- Environmental stress drives clearance of a persistent enteric virus in mice.Nature microbiology · 2025Article
- Trim7 does not have a role in the restriction of murine norovirus infectionJournal of virology · 2025Article
- Norovirus co-opts NINJ1 for selective protein secretion.Science advances · 2025Article
- KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection.Science (New York, N.Y.) · 2025Article
- The role of the tuft cell-interleukin-25 axis in the pathogenesis of inflammatory bowel disease.Frontiers in immunology · 2025Review
- Regulation of the tuft cell-ILC2 circuit in intestinal mucosal immunity.Frontiers in immunology · 2025Review
- Tuft cells in the intestine, immunity and beyond.Nature reviews. Gastroenterology & hepatology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 8 institutions in 2 countries.
Madison S StrineDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8572-1314
Eric FagerbergDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0313-3717
Patrick W DarcyLaboratory of Mucosal Immunology, Rockefeller University, New York, NY, USA.ORCID 0000-0002-7696-3212
Gabriel M BarrónProgram in Immunology, Stanford University, Stanford, CA, USA.
Renata B FillerDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-8579-8418
Mia Madel AlfajaroDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-6402-2730
Nicole D'Angelo-GavrishYale Rodent Services and Animal Resource Center, Yale University, New Haven, CT, USA.
Fang WangDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-2604-4429
Vincent R GrazianoDepartment of Immunology, School of Medicine, UConn Health, Farmington, CT, USA.ORCID 0000-0003-1046-9753
Bridget L MenaschéDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-3520-2422
Martina DamoDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7217-3221
Ya-Ting WangSXMU-Tsinghua Collaborative Innovation Center for Frontier Medicine, Tsinghua University School of Medicine, Beijing, China.ORCID 0000-0002-5057-4083
Michael R HowittProgram in Immunology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-3643-2468
Sanghyun LeeDepartment of Molecular Microbiology and Immunology, Brown University, Providence, RI, USA.ORCID 0000-0002-0736-1648
Nikhil S JoshiDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7045-7837
Daniel MucidaLaboratory of Mucosal Immunology, Rockefeller University, New York, NY, USA.ORCID 0000-0002-0000-0452
Craig B WilenDepartment of Immunobiology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2495-9403
Yale University · USStanford University · USBrown University · USHoward Hughes Medical Institute · USRockefeller University · USTsinghua University · CNUConn Health · USYale Cancer Center · US
Funding
Stem Cell and Transplantation BiologyU54DK106829 · NIDDK · FRED HUTCHINSON CANCER RESEARCH CENTER · PI DEREK L STIREWALT · 2015 to 2026
$9.1MThe role of tuft cells in norovirus pathogenesisR01AI148467 · NIAID · YALE UNIVERSITY · PI Craig Brian Wilen · 2020 to 2026
$3.9MDeveloping translationally-relevant genetically engineered mouse models of lung adenocarcinoma for investigations in cancer immunologyR01CA237037 · NCI · YALE UNIVERSITY · PI JOSHI, NIKHIL · 2020 to 2024
$2.7MHuman and Translational Immunology Training ProgramT32AI155387 · NIAID · YALE UNIVERSITY · PI Joseph Edgar Craft, Kevan C Herold · 2021 to 2026
$2.6MImpact of symbiotic protists on intestinal T cell homeostasis and inflammation.R01DK128292 · NIDDK · STANFORD UNIVERSITY · PI HOWITT, MICHAEL R · 2021 to 2025
$2.3MViral immune evasion during intestinal norovirus infectionR01AI183155 · NIAID · BROWN UNIVERSITY · PI Sanghyun Lee · 2024 to 2026
$1.7MRole of virus-receptor interactions in determining norovirus tropism and pathogenesis in vivoK08AI128043 · NIAID · YALE UNIVERSITY · PI WILEN, CRAIG BRIAN · 2017 to 2021
$940kHigh Throughput DNA Sequencer UpgradeS10OD018220 · OD · STANFORD UNIVERSITY · PI COLLER, JOHN · 2014 to 2014
$596kComputer ClusterS10OD021763 · OD · STANFORD UNIVERSITY · PI JI, HANLEE P · 2016 to 2016
$481kEntry inhibition of SARS-CoV-2 by human LRRC15R21AI173821 · NIAID · BROWN UNIVERSITY · PI LEE, SANGHYUN · 2023 to 2024
$460kTuft cell regulation of Peyers patch composition and organizationR21AI171222 · NIAID · STANFORD UNIVERSITY · PI HOWITT, MICHAEL R · 2022 to 2023
$438kNCI NIH HHS R01 CA237037NIAID NIH HHS K08 AI128043NIAID NIH HHS R01 AI148467NIAID NIH HHS R01 AI183155NIAID NIH HHS R21 AI171222NIAID NIH HHS R21 AI173821NIAID NIH HHS T32 AI155387NIDDK NIH HHS R01 DK128292NIDDK NIH HHS U54 DK106829NIH HHS S10 OD018220NIH HHS S10 OD021763
Abstract
The persistent murine norovirus strain MNV
Indexed as
CD8-Positive T-LymphocytesNorovirusAnimalsHumansImmune PrivilegeIntestinesMiceTuft Cells
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.