Evidence map›Paper›PMID 38517896›Full record

ArticleCell reports2024

Peripheral neuronal activation shapes the microbiome and alters gut physiology.

Jessica A Griffiths, Bryan B Yoo, Peter Thuy-Boun, Victor J Cantu, Kelly C Weldon, Collin Challis, Michael J Sweredoski, Ken Y Chan, Taren M Thron, Gil Sharon and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Microbiome and chronic pelvic pain in women: a mini-review.Human reproduction (Oxford, England) · 2026
    Review
  4. Article
  5. Gut-Brain Signaling in Parkinson's Disease: A Narrative Review.International journal of molecular sciences · 2026
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
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  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Jessica A GriffithsDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Bryan B YooDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Peter Thuy-BounDepartments of Molecular Medicine and Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Victor J CantuDepartment of Pediatrics, University of California, San Diego, San Diego, CA, USA.
Kelly C WeldonCollaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, CA, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, San Diego, CA, USA.
Collin ChallisDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Michael J SweredoskiDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Ken Y ChanDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Taren M ThronDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Gil SharonDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Annie MoradianDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
Gregory HumphreyDepartment of Pediatrics, University of California, San Diego, San Diego, CA, USA.
Qiyun ZhuDepartment of Pediatrics, University of California, San Diego, San Diego, CA, USA.
Justin P ShafferDepartment of Pediatrics, University of California, San Diego, San Diego, CA, USA.
Dennis W WolanDepartments of Molecular Medicine and Integrative Structural and Computational Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Pieter C DorresteinDepartment of Pediatrics, University of California, San Diego, San Diego, CA, USA; Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, San Diego, CA, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, San Diego, CA, USA.
Rob KnightDepartment of Pediatrics, University of California, San Diego, San Diego, CA, USA; UCSD Center for Microbiome Innovation, University of California, San Diego, San Diego, CA, USA; Department of Computer Science and Engineering, University of California, San Diego, San Diego, CA, USA; Shu Chien-Gene Lay Department of Engineering, University of California, San Diego, San Diego, CA, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, San Diego, CA, USA.
Viviana GradinaruDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA.
Sarkis K MazmanianDivision of Biology & Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Aligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD 20815, USA. Electronic address: sarkis@caltech.edu.
California Institute of Technology · USUniversity of California San Diego · USScripps Research Institute · USUniversity of San Diego · US

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
Protection from Mucosal Pathology by Gut Microflora during Experimental ColitisR01DK078938 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2009 to 2020
$5.1M
Collaborative Microbial Metabolite CenterU24DK133658 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2022 to 2026
$2.9M
Reverse Metabolomics for the Discovery of Disease Associated Microbial MoleculesR01DK136117 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PIETER C DORRESTEIN · 2023 to 2026
$2.9M
Protection from Mucosal Pathology by Gut Microbiota During Experimentas ColitisR56DK078938 · NIDDK · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MAZMANIAN, SARKIS K · 2016 to 2016
$618k
NIDDK NIH HHS R01 DK078938NIDDK NIH HHS R01 DK136117NIDDK NIH HHS R56 DK078938NIDDK NIH HHS U24 DK133658NIGMS NIH HHS K12 GM068524NIGMS NIH HHS T32 GM007616
6 · The paper itself

Abstract

The gastrointestinal (GI) tract is innervated by intrinsic neurons of the enteric nervous system (ENS) and extrinsic neurons of the central nervous system and peripheral ganglia. The GI tract also harbors a diverse microbiome, but interactions between the ENS and the microbiome remain poorly understood. Here, we activate choline acetyltransferase (ChAT)-expressing or tyrosine hydroxylase (TH)-expressing gut-associated neurons in mice to determine effects on intestinal microbial communities and their metabolites as well as on host physiology. The resulting multi-omics datasets support broad roles for discrete peripheral neuronal subtypes in shaping microbiome structure, including modulating bile acid profiles and fungal colonization. Physiologically, activation of either ChAT

Indexed as

Gastrointestinal MicrobiomeNeuronsAnimalsCholine O-AcetyltransferaseEnteric Nervous SystemGastrointestinal TractMaleMiceMice, Inbred C57BLTyrosine 3-MonooxygenaseCholine O-AcetyltransferaseTyrosine 3-MonooxygenaseAkkermansia muciniphilacholinergicCP: MicrobiologyCP: Neurosciencedopaminergicenteric nervous systemgut microbiomegut motilitynoradrenergicperipheral nervous system

Identifiers

PMID38517896
PMCPMC11132177
OpenAlexW4393040330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.