ReviewCurrent HIV/AIDS reports2024
Leveling Up PrEP: Implementation Strategies at System and Structural Levels to Expand PrEP Use in the United States.
Review in Current HIV/AIDS reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 16 citations in OpenAlex.
- Strategies to Support HIV Pre-Exposure Prophylaxis Implementation: A National Programmatic Experience in Sexually Transmitted Infection Clinics.Sexually transmitted diseases · 2026Article
- HIV Pre-Exposure Prophylaxis Use Among South Asian Sexual Minority Men in the United States: Pilot Web-Based Survey Study.JMIR formative research · 2026Article
- Achieving reimbursable PrEP is insufficient to increase and diversify the users attending community-based services.HIV medicine · 2026Article
- Trends and Correlates of Post-exposure Prophylaxis Utilization Among Men Who Have Sex with Men in Qingdao, China: A 2023-2024 Prospective Cohort Study.AIDS and behavior · 2026Article
- Aligning Efforts to Boost Medications for Opioid Use Disorder and Pre-Exposure Prophylaxis for HIV.Journal of general internal medicine · 2026Article
- Factors influencing PrEP adoption in sexual health clinics within Ontario's public health system: a qualitative study using the Consolidated Framework for Implementation Research (CFIR).Frontiers in public health · 2026Article
- Expanding PrEP Access by Embedding Unannounced SNAPS Navigators in High STI Testing Clinical Sites.AIDS and behavior · 2026Article
- Changes in geographic drive time access to pre-exposure prophylaxis (PrEP) in the United States, 2017 to 2025.Preventive medicine reports · 2026Article
- Article
- Becoming one with the community: a grounded theory-derived context-specific framework exploring AIDS service organization strategies for implementing pre-exposure prophylaxis outreach among African American populations.BMC health services research · 2025Article
- Exploration of implementation determinants and strategies for same-day oral PrEP in community-based organizations and federally qualified health centers.Implementation science communications · 2025Article
- The great mismatch: unfulfilled promise of biomedical HIV prevention.AIDS (London, England) · 2025Article
- Article
- Pre-Exposure Prophylaxis Awareness and Demand Creation: Overlooked Populations and Opportunities to Move Forward.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Activity Space Mapping and Pre-Exposure Prophylaxis Uptake Among Gay, Bisexual, and Other Sexual Minority Men in Small Cities and Towns in the United States.AIDS and behavior · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
purpose of reviewDespite highly effective biomedical HIV pre-exposure prophylaxis (PrEP) options, suboptimal PrEP uptake impedes progress towards ending the epidemic in the United States of America (USA). Implementation science bridges what we know works in controlled clinical trial settings to the context and environment in which efficacious tools are intended to be deployed. In this review, we focus on strategies that target PrEP use barriers at the system or structural level, exploring the implications and opportunities in the context of the fragmented USA healthcare system. RECENT
findingsTask shifting could increase PrEP prescribers, but effectiveness evidence is scarce in the USA, and generally focused in urban settings. Integration of PrEP within existing healthcare infrastructure concentrates related resources, but demonstration projects rarely present the resource implications of redirecting staff. Changing the site of service via expanded telehealth could improve access to more rural populations, though internet connectivity, technology access, and challenges associated with determining biomedical eligibility remain logistical barriers for some of the highest burden communities in the USA. Finally, a tailored care navigation and coordination approach has emerged as a highly effective component of PrEP service provision, attempting to directly modify the system-level determinants of PrEP use experienced by the individual. We highlight recent advances and evidence surrounding task shifting, integration, service delivery, and tailoring. With the exception of tailored care navigation, evidence is mixed, and the downstream impact and sustainability of task shifting and care integration require further attention. To maximize PrEP outcomes, research will need to continue to examine the interplay between individuals, clinics, and the healthcare system and associated policies within which they operate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.