Evidence map›Paper›PMID 38517622›Full record

ArticleJournal of natural medicines2024

Alliaxylines A-E: five new mexicanolides from the stem barks of Dysoxylum alliaceum (Blume) Blume ex A.Juss.

Sandra Amalia Riyadi, Al Arofatus Naini, Tri Mayanti, Ronny Lesmana, Mohamad Nurul Azmi, Sofa Fajriah, Siriporn Jungsuttiwong, Unang Supratman

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Article in Journal of natural medicines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sandra Amalia RiyadiDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia.
Al Arofatus NainiDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia.
Tri MayantiCentral Laboratory, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia.
Ronny LesmanaCentral Laboratory, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia.
Mohamad Nurul AzmiSchool of Chemical Sciences, Universiti Sains Malaysia, Minden, 11800, Penang, Malaysia.
Sofa FajriahResearch Center for Chemistry, National Research and Innovation Agency (BRIN), Kawasan PUSPITEK Serpong Tangerang, Selatan, 15314, Indonesia.
Siriporn JungsuttiwongDepartment of Chemistry, Faculty of Science, Ubon Ratchathani University, Ubon Ratchathani, 34190, Thailand.
Unang SupratmanDepartment of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Sumedang, Indonesia. unang.supratman@unpad.ac.id.ORCID http://orcid.org/0000-0003-1104-2321

Funding

Universitas Padjadjaran 1959/UN6.3.1/PT.00/2022
6 · The paper itself

Abstract

A total of five new mexicanolides (1-5), namely alliaxylines A-E, together with two known limonoids 6 and 7, were isolated and identified from Dysoxylum alliaceum (Blume) Blume ex. A.Juss. (Meliaceae). The structures of these compounds were elucidated based on extensive spectroscopic analyses, including HR-ESI-MS, UV, IR, 1D, and 2D NMR, as well as theoretical stimulation of NMR shifts with the DP4 + algorithm. Consequently, this study aimed to examine cytotoxic activities of these compounds against MCF-7 and A549 cell lines. The results implied that compound 2 was the most potent against the two tested cells, with IC

Indexed as

LimoninsMeliaceaePlant BarkA549 CellsAntineoplastic Agents, PhytogenicCell Line, TumorHumansMagnetic Resonance SpectroscopyMCF-7 CellsMolecular StructurePlant ExtractsPlant StemsAntineoplastic Agents, PhytogenicLimoninsmexicanolidePlant ExtractsAlliaxylines A–ECytotoxic activityDysoxylum alliaceumLimonoidsMeliaceae

Identifiers

PMID38517622

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.