Evidence map›Paper›PMID 38517590›Full record

ArticleNatural products and bioprospecting2024

Compounds from Agathis dammara exert hypoglycaemic activity by enhancing glucose uptake: lignans, terpenes and others.

Zhe-Wei Yu, Bang-Ping Cai, Su-Zhi Xie, Yi Zhang, Wen-Hui Wang, Shun-Zhi Liu, Yan-Lin Bin, Qi Chen, Mei-Juan Fang, Rong Qi and 2 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Natural products and bioprospecting, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zhe-Wei Yu *School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Bang-Ping Cai *Xiamen Botanical Garden, Xiamen, 361003, Fujian, China.
Su-Zhi XieXiamen Medical College Affiliated Haicang Hospital, Xiamen, 361026, China.
Yi ZhangSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Wen-Hui WangSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Shun-Zhi LiuSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Yan-Lin BinSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Qi ChenSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Mei-Juan FangSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Rong QiSchool of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Ming-Yu LiSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China. limingyu@xmu.edu.cn.
Ying-Kun QiuSchool of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China. qyk@xmu.edu.cn.ORCID http://orcid.org/0000-0003-0181-2927
Xiamen University · CNPeking University · CNXiamen Chang Gung Hospital · CN

Funding

Traditional Chinese Medicine Foundation of Xiamen XWZY-2023-0303
6 · The paper itself

Abstract

In this study, two new kaurane diterpenes (16, 17), together with 12 lignans (1-12), a triterpene (15), and two other compounds (13, 14) were isolated from the woods of Agathis dammara. The structure of the new compound was determined by HR ESIMS and 1D/2D NMR spectroscopy, and its absolute configuration was determined by electronic circular dichroism (ECD) exciton chirality method. Compounds 5, 11, 14 exhibit significant hypoglycaemic activity in zebrafish, and their mechanism of action is to enhance glucose uptake in zebrafish.

Indexed as

Agathis dammaraGlucose uptakeHypoglycaemicLignansTerpenes

Identifiers

PMID38517590
PMCPMC10959857
OpenAlexW4393073362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.