Evidence map›Paper›PMID 38517485›Full record

ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2024

Brain AVM compactness score in children with hereditary hemorrhagic telangiectasia.

Lauren A Beslow, Arastoo Vossough, Helen Kim, Jeffrey Nelson, Michael T Lawton, Jeffrey Pollak, Doris D M Lin, Felix Ratjen, Adrienne M Hammill, Steven W Hetts and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 94% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 15 institutions in 2 countries.

Lauren A BeslowNeurology and Pediatrics, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Penn HHT Center of Excellence and Children's Hospital of Philadelphia Hereditary Hemorrhagic Telangiectasia Program, 3401 Civic Center Boulevard, Philadelphia, 19104, PA, USA. beslow@chop.edu.
Arastoo VossoughRadiology, Children's Hospital of Philadelphia and Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Helen KimCenter for Cerebrovascular Research, Anesthesia, University of California, San Francisco, CA, USA.
Jeffrey NelsonCenter for Cerebrovascular Research, Anesthesia, University of California, San Francisco, CA, USA.
Michael T LawtonNeurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Jeffrey PollakVascular & Interventional Radiology, Yale University School of Medicine, New Haven, CT, USA.
Doris D M LinRadiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Felix RatjenPaediatrics and Paediatric Respiratory Medicine, The Hospital for Sick Children and University of Toronto, Toronto, ON, Canada.
Adrienne M HammillCancer and Blood Diseases Institute, Division of Hematology, Cincinnati Children's Hospital Medical Center, and Division of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Steven W HettsDivision of Neurointerventional Radiology, University of California, San Francisco, CA, USA.
James R GossageDepartments of Critical Care Medicine and Pulmonary Medicine, Augusta University, Augusta, GA, USA.
Kevin J WhiteheadDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Utah Health, Salt Lake City, UT, USA.
Marie E Faughnan *Toronto HHT Centre, Department of Medicine, St. Michael's Hospital and Li Ka Shing Knowledge Institute, University of Toronto, Toronto, ON, Canada.
Timo Krings *Division of Neuroradiology, Toronto Western Hospital and University of Toronto, Toronto, ON, Canada.
Brain Vascular Malformation Consortium HHT Investigator Group
University of California, San Francisco · USAugusta University · USBarrow Neurological Institute · USSickKids Foundation · CAToronto Western Hospital · CAUniversity of Utah · USYale University · USChildren's Hospital of Philadelphia · USCincinnati Children's Hospital Medical Center · USJohns Hopkins Medicine · USJohns Hopkins University · USSt. Michael's Hospital · CAUniversity of Cincinnati · USUniversity of Pennsylvania · USUniversity of Toronto · CA

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
The Impact of COVID-19 on People Living with Rare Diseases and Their FamiliesU2CTR002818 · NCATS · CINCINNATI CHILDRENS HOSP MED CTR · PI Michal Kouril · 2019 to 2026
$51.2M
VCRC Administration UnitU54NS065705 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, HELEN · 2009 to 2023
$20.8M
Children's Hospital of Philadelphia Pediatrics Department Chair's InitiativeNCATS NIH HHS U2C TR002818NCATS NIH HHS UL1 TR001863NIH HHS U54NS065705NINDS NIH HHS U54 NS065705
6 · The paper itself

Abstract

objectiveThe brain arteriovenous malformation (BAVM) nidus compactness score (CS), determined on angiography, predicts BAVM recurrence after surgical resection among children with sporadic BAVMs. We measured the angiographic CS for BAVMs among children with hereditary hemorrhagic telangiectasia (HHT) to determine CS characteristics in this population.

methodsA pediatric interventional neuroradiologist reviewed angiograms to determine the CS of BAVMs in children with HHT recruited to the BVMC. CS is based on overall nidus and perinidal anomalous vessel compactness. CS categories included 1 = diffuse nidus, 2 = intermediate nidus, and 3 = compact nidus.

resultsForty-eight of 78 children (61.5%) with HHT and brain vascular malformations had a conventional angiogram; 47 (97.9%) angiograms were available. Fifty-four BAVMs were identified in 40 of these 47 children (85.1%). Of 54 BAVMs in children with HHT, CS was 1 in 7 (13%), 2 in 29 (53.7%), and 3 in 18 BAVMs (33.3%) compared with CS of 1 in six (26.1%), 2 in 15 (65.2%), and 3 in 2 BAVMs (8.7%) among 23 previously reported children with sporadic BAVMs, p = 0.045 (Fisher's exact). Seven children with HHT had intracranial hemorrhage: 4 had CS = 3, 1 had CS = 2, and 2 had CS = 1.

conclusionsA range of CSs exists across HHT BAVMs, suggesting it may be an angiographic measure of interest for future studies of BAVM recurrence and hemorrhage risk. Children with HHT may have more compact niduses compared to children with sporadic BAVMs. Additional research should determine whether CS affects hemorrhage risk or post-surgical recurrence risk in HHT-associated BAVMs, which could be used to direct BAVM treatment.

Indexed as

Cerebral AngiographyIntracranial Arteriovenous MalformationsTelangiectasia, Hereditary HemorrhagicAdolescentChildChild, PreschoolFemaleHumansInfantMaleAngiographyBrain arteriovenous malformationHereditary hemorrhagic telangiectasia

Identifiers

PMID38517485
PMCPMC11179972
OpenAlexW4393074704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.