Evidence map›Paper›PMID 38517165›Full record

ArticleJournal of virology2024

Mutagenesis and functional analysis of the varicella-zoster virus portal protein.

Melissa A Visalli, Dakota J Nale Lovett, Ellyn M Kornfeind, Haley Herrington, Yi Tian Xiao, Daniel Lee, Patience Plair, S Garrett Wilder, Bret K Garza, Ashton Young and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Melissa A VisalliDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Dakota J Nale LovettDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Ellyn M KornfeindDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Haley HerringtonDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Yi Tian XiaoDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Daniel LeeDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Patience PlairDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
S Garrett WilderDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Bret K GarzaDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Ashton YoungDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.
Robert J VisalliDepartment of Biomedical Sciences, Mercer University School of Medicine, Savannah, Georgia, USA.ORCID 0000-0002-7570-8922
Mercer University · US

Funding

Varicella-Zoster Virus Encapsidation ProteinsR15AI062713 · NIAID · PURDUE UNIVERSITY WEST LAFAYETTE · PI VISALLI, ROBERT J. · 2005 to 2010
$440k
Targeting the Structurally Conserved Portal Protein as a Strategy to Develop a First-In-Class Broad-Spectrum Herpesvirus Antiviral Drug, PORT 1R15AI152023 · NIAID · MERCER UNIVERSITY MACON · PI VISALLI, ROBERT J. · 2021 to 2021
$408k
NIAID NIH HHS R15 AI062713NIAID NIH HHS R15 AI152023
6 · The paper itself

Abstract

Herpesviruses replicate by cleaving concatemeric dsDNA into single genomic units that are packaged through an oligomeric portal present in preformed procapsids. In contrast to what is known about phage portal proteins, details concerning herpesvirus portal structure and function are not as well understood. A panel of 65 Varicella-Zoster virus (VZV) recombinant portal proteins with five amino acid in-frame insertions were generated by random transposon mutagenesis of the VZV portal gene, ORF54. Subsequently, 65 VZV

Indexed as

Herpesviridae InfectionsHerpesvirus 3, HumanAmino AcidsAnimalsDNAHumansMammalsMutagenesisVirus ReplicationAmino AcidsDNADNA encapsidationportal proteinvaricella-zoster virus

Identifiers

PMID38517165
PMCPMC11019927
OpenAlexW4393084353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.