Evidence map›Paper›PMID 38516817›Full record

ArticleCNS neuroscience & therapeutics2024

Altered functional connectivity of brainstem nuclei in new daily persistent headache: Evidence from resting-state functional magnetic resonance imaging.

Wei Wang, Dong Qiu, Yanliang Mei, Xiaoyan Bai, Ziyu Yuan, Xue Zhang, Zhonghua Xiong, Hefei Tang, Peng Zhang, Yaqing Zhang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Wei WangDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0003-2302-6273
Dong QiuDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-7484-2572
Yanliang MeiDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xiaoyan BaiTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Ziyu YuanDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xue ZhangTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Zhonghua XiongDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Hefei TangDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Peng ZhangDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Yaqing ZhangDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Xueying YuDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Zhe WangDepartment of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Zhaoli GeDepartment of Neurology, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
Binbin SuiTiantan Neuroimaging Center of Excellence, China National Clinical Research Center for Neurological Diseases, Beijing, China.
Yonggang WangDepartment of Neurology, Headache Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Capital Medical University · CNDalian Medical University · CNNational Clinical Research Center for Digestive Diseases · CNShenzhen Second People's Hospital · CN

Funding

National Natural Science Foundation of China 31770800National Natural Science Foundation of China 32170752National Natural Science Foundation of China 91849104the National Natural Science Foundation of Beijing Z200024
6 · The paper itself

Abstract

objectivesThe new daily persistent headache (NDPH) is a rare primary headache disorder. However, the underlying mechanisms of NDPH remain incompletely understood. This study aims to apply seed-based analysis to explore the functional connectivity (FC) of brainstem nuclei in patients with NDPH using resting-state functional magnetic resonance imaging (MRI).

methodsThe FC analysis from the region of interest (ROI) to whole brain voxels was used to investigate 29 patients with NDPH and 37 well-matched healthy controls (HCs) with 3.0 Tesla MRI. The 76 nuclei in the brainstem atlas were defined as ROIs. Furthermore, we explored the correlations between FC and patients' clinical characteristics and neuropsychological evaluations.

resultsPatients with NDPH exhibited reduced FC in multiple brainstem nuclei compared to HCs (including right inferior medullary reticular formation, right mesencephalic reticular formation, bilateral locus coeruleus, bilateral laterodorsal tegmental nucleus-central gray of the rhombencephalon, median raphe, left medial parabrachial nucleus, periaqueductal gray, and bilateral ventral tegmental area-parabrachial pigmented nucleus complex) and increased FC in periaqueductal gray. No significant correlations were found between the FC of these brain regions and clinical characteristics or neuropsychological evaluations after Bonferroni correction (p > 0.00016).

conclusionsOur results demonstrated that patients with NDPH have abnormal FC of brainstem nuclei involved in the perception and regulation of pain and emotions.

Indexed as

BrainBrain StemBrain MappingHeadacheHumansMagnetic Resonance ImagingMedulla Oblongatabrainstemfunctional connectivityfunctional magnetic resonance imagingnew daily persistent headache

Identifiers

PMID38516817
PMCPMC10958407
OpenAlexW4393098184

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.