Evidence map›Paper›PMID 38516691›Full record

ArticleMolecular therapy. Methods & clinical development2024

Manufacturing DNA in

Steven J Hersch, Siddarth Chandrasekaran, Jamie Lam, Nafiseh Nafissi, Roderick A Slavcev

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Steven J HerschMediphage Bioceuticals, Inc, Toronto, ON, Canada.
Siddarth ChandrasekaranMediphage Bioceuticals, Inc, Toronto, ON, Canada.
Jamie LamMediphage Bioceuticals, Inc, Toronto, ON, Canada.
Nafiseh NafissiMediphage Bioceuticals, Inc, Toronto, ON, Canada.
Roderick A SlavcevMediphage Bioceuticals, Inc, Toronto, ON, Canada.
Blutip (Canada) · CAUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biotechnologies such as gene therapy have brought DNA vectors to the forefront of pharmaceuticals. The quality of starting material plays a pivotal role in determining final product quality. Here, we examined the fidelity of DNA replication using enzymatic methods (

Indexed as

AAV manufacturingDNA manufacturingDNA replication fidelityDNA synthesisE. coliloss of functionmutation ratepolymerase chain reactionrolling circle amplificationSacB

Identifiers

PMID38516691
PMCPMC10951457
OpenAlexW4392391188

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.