Evidence map›Paper›PMID 38516585›Full record

ArticleRSC medicinal chemistry2024

Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues.

Anjie S Bispat, Fernanda C Cardoso, Md Mahadhi Hasan, Yashad Dongol, Ricki Wilcox, Richard J Lewis, Peter J Duggan, Kellie L Tuck

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. RSC medicinal chemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Anjie S BispatSchool of Chemistry, Monash University Victoria 3800 Australia Kellie.Tuck@monash.edu.ORCID https://orcid.org/0000-0002-4300-8403
Fernanda C CardosoInstitute for Molecular Bioscience, The University of Queensland St Lucia QLD 4072 Australia.ORCID https://orcid.org/0000-0002-0068-9974
Md Mahadhi HasanInstitute for Molecular Bioscience, The University of Queensland St Lucia QLD 4072 Australia.
Yashad DongolInstitute for Molecular Bioscience, The University of Queensland St Lucia QLD 4072 Australia.
Ricki WilcoxSchool of Chemistry, Monash University Victoria 3800 Australia Kellie.Tuck@monash.edu.
Richard J LewisInstitute for Molecular Bioscience, The University of Queensland St Lucia QLD 4072 Australia.
Peter J DugganCSIRO Manufacturing, Research Way Clayton Victoria 3168 Australia Peter.Duggan@csiro.au.ORCID https://orcid.org/0000-0002-6056-5367
Kellie L TuckSchool of Chemistry, Monash University Victoria 3800 Australia Kellie.Tuck@monash.edu.ORCID https://orcid.org/0000-0002-9104-3158
The University of Queensland · AUMonash University · AUCSIRO Manufacturing · AUFlinders University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Building on previous investigations, structural modifications to the neuronal calcium ion channel blocker MONIRO-1 and related compounds were conducted that included replacement of the amide linker with an aniline and isosteric sulfonamide moiety, and the previously used strategy of substitution of the guanidinium group with less hydrophilic amine functionalities. A comprehensive SAR study revealed a number of phenoxyaniline and sulfonamide compounds that were more potent or had similar potency for the Ca

Identifiers

PMID38516585
PMCPMC10953480
OpenAlexW4391379092

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.