Evidence map›Paper›PMID 38516347›Full record

ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2023

The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis.

Andrew J Devine, Alice E Parnell, Catherine R Back, Nicholas R Lees, Samuel T Johns, Ainul Z Zulkepli, Rob Barringer, Katja Zorn, James E M Stach, Matthew P Crump and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Andrew J DevineSchool of Chemistry University of Bristol BS81TS Bristol UK.ORCID 0000-0002-4200-5542
Alice E ParnellSchool of Biochemistry University of Bristol BS81TD Bristol UK.
Catherine R BackSchool of Biochemistry University of Bristol BS81TD Bristol UK.
Nicholas R LeesSchool of Chemistry University of Bristol BS81TS Bristol UK.
Samuel T JohnsSchool of Biochemistry University of Bristol BS81TD Bristol UK.
Ainul Z ZulkepliSchool of Biochemistry University of Bristol BS81TD Bristol UK.
Rob BarringerSchool of Biochemistry University of Bristol BS81TD Bristol UK.
Katja ZornBioPharmaceuticals R&D AstraZeneca Pepparedsleden 1 43183 Mölndal Sweden.
James E M StachSchool of Natural and Environmental Sciences Newcastle University NE17RU Newcastle-upon-Tyne UK.ORCID 0000-0001-8787-2407
Matthew P CrumpSchool of Chemistry University of Bristol BS81TS Bristol UK.ORCID 0000-0002-7868-5818
Martin A HayesBioPharmaceuticals R&D AstraZeneca Pepparedsleden 1 43183 Mölndal Sweden.
Marc W van der KampSchool of Biochemistry University of Bristol BS81TD Bristol UK.ORCID 0000-0002-8060-3359
Paul R RaceSchool of Biochemistry University of Bristol BS81TD Bristol UK.ORCID 0000-0003-0184-5630
Christine L WillisSchool of Chemistry University of Bristol BS81TS Bristol UK.ORCID 0000-0002-3919-3642
University of Bristol · GBAstraZeneca (Sweden) · SENewcastle University · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L01386X/1
6 · The paper itself

Abstract

Abyssomicin C and its atropisomer are potent inhibitors of bacterial folate metabolism. They possess complex polycyclic structures, and their biosynthesis has been shown to involve several unusual enzymatic transformations. Using a combination of synthesis and in vitro assays we reveal that AbyV, a cytochrome P450 enzyme from the

Indexed as

AntibioticsBiosynthesisP450 EnzymesPolyketidesStructure Elucidation

Identifiers

PMID38516347
PMCPMC10952897
OpenAlexW4307918867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.