ArticleFrontiers in neuroscience2024
Comparison of local activation, functional connectivity, and structural connectivity in the N-back task.
Article in Frontiers in neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Role of task-based functional MRI in the assessment of sports-related concussion: a systematic review.Frontiers in neurologyPooled it
- Temporal Interference Stimulation Boosts Working Memory Performance in the Frontoparietal Network.Human brain mapping · 2025Trial
- Human brain network for reading the mind from the eyes: beyond activated and deactivated regions.Social cognitive and affective neuroscience · 2026Article
- Habenula-ventral tegmental area functional coupling and risk aversion in humans.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Reorganized Functional Networks Underlie Working Memory Deficits After Right-Hemispheric Stroke.The European journal of neuroscience · 2025Article
- Unraveling trauma memory: Differential functional connectivity profiles of anterior and posterior hippocampus in post-traumatic stress disorder and its dissociative subtype.Neuroimage. Reports · 2025Article
- Effects of Cerebellar Repetitive Transcranial Magnetic Stimulation at Different Frequencies on Working Memory: An EEG Study.CNS neuroscience & therapeutics · 2025Article
- A chronometric relationship between circuits underlying learning and error monitoring in the basal ganglia and salience network.Imaging neuroscience (Cambridge, Mass.) · 2024Article
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5 authors.
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Abstract
The N-back task is widely used to investigate working memory. Previous functional magnetic resonance imaging (fMRI) studies have shown that local brain activation depends on the difficulty of the N-back task. Recently, changes in functional connectivity and local activation during a task, such as a single-hand movement task, have been reported to give the distinct information. However, previous studies have not investigated functional connectivity changes in the entire brain during N-back tasks. In this study, we compared alterations in functional connectivity and local activation related to the difficulty of the N-back task. Because structural connectivity has been reported to be associated with local activation, we also investigated the relationship between structural connectivity and accuracy in a N-back task using diffusion tensor imaging (DTI). Changes in functional connectivity depend on the difficulty of the N-back task in a manner different from local activation, and the 2-back task is the best method for investigating working memory. This indicates that local activation and functional connectivity reflect different neuronal events during the N-back task. The top 10 structural connectivities associated with accuracy in the 2-back task were locally activated during the 2-back task. Therefore, structural connectivity as well as fMRI will be useful for predicting the accuracy of the 2-back task.
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