ArticleRSC advances2024
Copper-catalyzed synthesis of primary amides through reductive N-O cleavage of dioxazolones.
Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Once Upon a Time Without DMF: Greener Paths in Peptide and Organic Synthesis.Molecules (Basel, Switzerland) · 2026Review
- Towards the activity of twisted acyclic amides.RSC advances · 2025Article
- Recent advances in synthetic approaches for bioactive cinnamic acid derivatives.Beilstein journal of organic chemistry · 2025Review
- Dioxazolones as electrophilic amide sources in copper-catalyzed and -mediated transformations.Beilstein journal of organic chemistry · 2025Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new method for the synthesis of primary amides is developed, in which dioxazolones are treated with a copper catalyst under mild reaction conditions. A broad scope of dioxazolones is exhibited as well as dioxazolones containing biologically active structural motifs. These robust and mild reaction conditions allow the transformation of dioxazolones to primary amides, in which sensitive functional groups such as hydroxyl, aldehyde, trialkylsilyl, and unsaturated carbon units are tolerated with excellent chemoselectivity.
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Registered trials
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