Evidence map›Paper›PMID 38516046›Full record

ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2023

Decreased Water Mobility Contributes To Increased α-Synuclein Aggregation.

Amberley D Stephens, Johanna Kölbel, Rani Moons, Chyi Wei Chung, Michael T Ruggiero, Najet Mahmoudi, Talia A Shmool, Thomas M McCoy, Daniel Nietlispach, Alexander F Routh and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Amberley D StephensDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0002-7303-6392
Johanna KölbelDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0002-9820-1892
Rani MoonsDepartment of Chemistry University of Antwerp Belgium.ORCID 0000-0003-2961-9950
Chyi Wei ChungDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0003-1780-3486
Michael T RuggieroDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0003-1848-2565
Najet MahmoudiISIS STFC Rutherford Appleton Laboratory UK.ORCID 0000-0003-4936-6911
Talia A ShmoolDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0002-0415-3050
Thomas M McCoyDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0002-4897-7924
Daniel NietlispachDepartment of Biochemistry University of Cambridge UK.ORCID 0000-0003-4364-9291
Alexander F RouthDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0002-3443-3053
Frank SobottDepartment of Chemistry University of Antwerp Belgium.ORCID 0000-0001-9029-1865
J Axel ZeitlerDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0002-4958-0582
Gabriele S Kaminski SchierleDepartment of Chemical Engineering and Biotechnology University of Cambridge UK.ORCID 0000-0002-1843-2202
University of Cambridge · GBRutherford Appleton Laboratory · GBUniversity of Antwerp · BEUniversity of Leeds · GBUniversity of Vermont · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The solvation shell is essential for the folding and function of proteins, but how it contributes to protein misfolding and aggregation has still to be elucidated. We show that the mobility of solvation shell H

Indexed as

AmyloidHydration ShellHydrogen BondSolvation ShellSolvent

Identifiers

PMID38516046
PMCPMC10952249
OpenAlexW4307747679

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.