Evidence map›Paper›PMID 38515960›Full record

ArticleOptica2019

High-resolution 3D refractive index microscopy of multiple-scattering samples from intensity images.

Shwetadwip Chowdhury, Michael Chen, Regina Eckert, David Ren, Fan Wu, Nicole Repina, Laura Waller

Open access · goldAbstract read
In one paragraph

Article in Optica, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  4. Article
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  6. Chromatix: a differentiable, GPU-accelerated wave-optics library.bioRxiv : the preprint server for biology · 2026
    Article
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  15. Article
  16. Review
  17. Article
  18. Ptychography at all wavelengths.Nature reviews. Methods primers · 2025
    Article
  19. Recover Biological Structure from Sparse-View Diffraction Images with Neural Volumetric Prior.Proceedings. IEEE International Conference on Computer Vision · 2025
    Article
  20. Article

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Shwetadwip ChowdhuryDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA.ORCID 0000-0002-6142-0231
Michael ChenDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA.ORCID 0000-0002-1633-3278
Regina EckertDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA.ORCID 0000-0003-4571-7040
David RenDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA.
Fan WuDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
Nicole RepinaDepartment of Bioengineering, University of California, Berkeley, California 94720, USA.
Laura WallerDepartment of Electrical Engineering and Computer Sciences, University of California, Berkeley, California 94720, USA.ORCID 0000-0003-1243-2356
University of California, Berkeley · US

Funding

Structured Illumination Computational Microscopy with UV Surface Excitation (MUSE) for Multispectral Super-Resolution HistologyF32GM129966 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHOWDHURY, SHWETADWIP · 2018 to 2020
$146k
NIGMS NIH HHS F32 GM129966
6 · The paper itself

Abstract

Optical diffraction tomography (ODT) reconstructs a sample's volumetric refractive index (RI) to create high-contrast, quantitative 3D visualizations of biological samples. However, standard implementations of ODT use interferometric systems, and so are sensitive to phase instabilities, complex mechanical design, and coherent noise. Furthermore, their reconstruction framework is typically limited to weakly scattering samples, and thus excludes a whole class of multiple-scattering samples. Here, we implement a new 3D RI microscopy technique that utilizes a computational multi-slice beam propagation method to invert the optical scattering process and reconstruct high-resolution (NA > 1.0) 3D RI distributions of multiple-scattering samples. The method acquires intensity-only measurements from different illumination angles and then solves a nonlinear optimization problem to recover the sample's 3D RI distribution. We experimentally demonstrate the reconstruction of samples with varying amounts of multiple-scattering: a 3T3 fibroblast cell, a cluster of

Identifiers

PMID38515960
PMCPMC10956703
OpenAlexW2971940004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.