Evidence map›Paper›PMID 38515846›Full record

ArticleFrontiers in pharmacology2024

Identification and validation of prognostic and immunotherapeutic responses in esophageal squamous carcinoma based on hypoxia phenotype-related genes.

Kai Xie, Zhe Chen, Jian Feng, Liangbin Pan, Nan Wang, Jing Luo, Yu Yao, Haitao Ma, Yu Feng, Wei Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kai Xie *Department of Thoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Zhe Chen *Department of Thoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Jian Feng *Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Liangbin PanDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Nan WangDepartment of Thoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Jing LuoDepartment of Cardiothoracic Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing, China.
Yu YaoDepartment of Respiratory Medicine, Nanjing Second Hospital, Nanjing, China.
Haitao MaDepartment of Thoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.
Yu FengDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wei JiangDepartment of Thoracic Surgery, The Fourth Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to investigate the clinical significance of the interaction between hypoxia and the immune system in esophageal squamous cell carcinoma (ESCC) microenvironment. A comprehensive evaluation of 13 hypoxia phenotype-related genes (HPRs) was conducted using data from TCGA-ESCC and two GEO cohorts. Three distinct HPRclusters were identified, and the HPRscore was established as an independent prognostic factor (

Indexed as

esophageal squamous cell carcinomahypoxiaimmunotherapyPheWASPKP1Prognosistumor microenvironment

Identifiers

PMID38515846
PMCPMC10955338

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.