Evidence map›Paper›PMID 38515703›Full record

ReviewHeliyon2024

Dose-response relationship of levodopa with dyskinesia in Parkinson's disease: A systematic review and meta-analysis.

Taozhi He, Dai Wang, Xinyu Zhang, Jiawen Liu, Shiyu Fang, Zhe Zhang, Hongjie Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Taozhi HeSchool of Medicine, Jinan University, 601 West Huangpu Avenue, Guangzhou, 510632, China.
Dai WangSchool of Medicine, Jinan University, 601 West Huangpu Avenue, Guangzhou, 510632, China.
Xinyu ZhangSchool of Medicine, Jinan University, 601 West Huangpu Avenue, Guangzhou, 510632, China.
Jiawen LiuSchool of Medicine, Jinan University, 601 West Huangpu Avenue, Guangzhou, 510632, China.
Shiyu FangSchool of Medicine, Jinan University, 601 West Huangpu Avenue, Guangzhou, 510632, China.
Zhe ZhangShandong University of Traditional Chinese Medicine, 4655 Daxue Road, Jinan, 250355, China.
Hongjie LiuSchool of Medicine, Jinan University, 601 West Huangpu Avenue, Guangzhou, 510632, China.
Jinan University · CNShandong University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite existing evidence linking dyskinesia to levodopa, the primary treatment for Parkinson's, the dose-response relationship and risk factors remain uncertain. In this study, the risk for dyskinesia in patients with Parkinson's disease receiving levodopa was evaluated via meta-analysis and meta-regression approaches to examine dyskinesia risk factors more reliably and improve treatment strategies and patient care. The PubMed and Embase databases were searched to identify randomized controlled trials comparing levodopa with other anti-Parkinson's drugs published in English before June 31, 2023. The primary outcome was dyskinesia, and a risk of bias assessment was performed. In total, 24 studies met the inclusion criteria; 21 had a low risk of bias, and 3 had a high risk of bias. These studies included 4698 patients with Hoehn and Yahr Grade I-III Parkinson's disease. Our meta-analysis showed that the risk of dyskinesia was higher for levodopa than for other anti-Parkinson's drugs (odds ratio: 2.52 [95% confidence interval: 1.84-3.46]). Dyskinesia was not related to age (slope coefficient: 0.185 [0.095];

Indexed as

Data miningDose–response relationshipDyskinesiaLevodopaMeta-regressionParkinson's disease

Identifiers

PMID38515703
PMCPMC10955298
OpenAlexW4392660441

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.