Evidence map›Paper›PMID 38515609›Full record

ArticleBioactive materials2024

Microenvironment-responsive metal-phenolic network release platform with ROS scavenging, anti-pyroptosis, and ECM regeneration for intervertebral disc degeneration.

Hao Zhou, Jinpeng He, Renfeng Liu, Jun Cheng, Yuhao Yuan, Wanpu Mao, Jun Zhou, Honghui He, Qianqi Liu, Wei Tan and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 42 citations in OpenAlex.

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  15. Tri-Functional MgTA@MnOInternational journal of nanomedicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Hao ZhouDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Jinpeng HeDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Renfeng LiuDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Jun ChengDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Yuhao YuanDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Wanpu MaoDepartment of Joint Surgery and Sports Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421002, China.
Jun ZhouInstitute of Medical Sciences, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Honghui HeDepartment of Joint Surgery and Sports Medicine, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421002, China.
Qianqi LiuDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Wei TanDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Cijun ShuaiState Key Laboratory of High Performance Complex Manufacturing, College of Mechanical and Electrical Engineering, Central South University, Changsha, 410083, China.
Youwen DengDepartment of Spine Surgery, The Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China.
Third Xiangya Hospital · CNCentral South University · CNUniversity of South China · CNXiangya Hospital Central South University · CNState Key Laboratory of High Performance Complex Manufacturing

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intervertebral disc degeneration (IVDD) can be caused by aging, injury, and genetic factors. The pathological changes associated with IVDD include the excessive accumulation of reactive oxygen species (ROS), cellular pyroptosis, and extracellular matrix (ECM) degradation. There are currently no approved specific molecular therapies for IVDD. In this study, we developed a multifunctional and microenvironment-responsive metal-phenolic network release platform, termed TMP@Alg-PBA/PVA, which could treat (IL-1β)-induced IVDD. The metal-phenolic network (TA-Mn-PVP, TMP) released from this platform targeted mitochondria to efficiently scavenge ROS and reduce ECM degradation. Pyroptosis was suppressed through the inhibition of the IL-17/ERK signaling pathway. These findings demonstrate the versatility of the platform. And in a rat model of IVDD, TMP@Alg-PBA/PVA exhibited excellent therapeutic effects by reducing the progression of the disease. TMP@Alg-PBA/PVA, therefore, presents clinical potential for the treatment of IVDD.

Indexed as

IL-17/ERK signaling pathwayIntervertebral disc degenerationMetal-phenolic networkPyroptosisReactive oxygen species

Identifiers

PMID38515609
PMCPMC10954684
OpenAlexW4392853764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.