ArticleAngewandte Chemie (Weinheim an der Bergstrasse, Germany)2023
Chemical Validation of
Jamal El Bakali, Michal Blaszczyk, Joanna C Evans, Jennifer A Boland, William J McCarthy, Imam Fathoni, Marcio V B Dias, Eachan O Johnson, Anthony G Coyne, Valerie Mizrahi and 3 more
Open access · hybridAbstract read
In one paragraphArticle in Angewandte Chemie (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors at 6 institutions in 6 countries.
Jamal El BakaliYusuf Hamied Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW UK.ORCID 0000-0002-1470-0521 Michal BlaszczykDepartment of Biochemistry University of Cambridge 80 Tennis Court Road Cambridge CB2 1GA UK.ORCID 0000-0001-5728-1518 Joanna C EvansMRC/NHLS/UCT Molecular Mycobacteriology Research Unit DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa Institute of Infectious Disease and Molecular Medicine and Department of Pathology Faculty of Health Sciences University of Cape Town Anzio Road Cape Town, Observatory 7925 South Africa.ORCID 0000-0002-4139-9527 Jennifer A BolandYusuf Hamied Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW UK.
William J McCarthyYusuf Hamied Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW UK.ORCID 0000-0002-2858-076X Imam FathoniResearch School of Biology The Australian National University Linnaeus Way ACT 2601 Australia.ORCID 0000-0003-3343-8917 Marcio V B DiasDepartment of Biochemistry University of Cambridge 80 Tennis Court Road Cambridge CB2 1GA UK.ORCID 0000-0002-5312-0191 Eachan O JohnsonSystems Chemical Biology of Infection and Resistance Laboratory The Francis Crick Institute 1 Midland Road London NW1 1AT UK.ORCID 0000-0002-0335-8337 Anthony G CoyneYusuf Hamied Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW UK.ORCID 0000-0003-0205-5630 Valerie MizrahiMRC/NHLS/UCT Molecular Mycobacteriology Research Unit DST/NRF Centre of Excellence for Biomedical TB Research & Wellcome Centre for Infectious Diseases Research in Africa Institute of Infectious Disease and Molecular Medicine and Department of Pathology Faculty of Health Sciences University of Cape Town Anzio Road Cape Town, Observatory 7925 South Africa.ORCID 0000-0003-4824-9115 Tom L BlundellDepartment of Biochemistry University of Cambridge 80 Tennis Court Road Cambridge CB2 1GA UK.ORCID 0000-0002-2708-8992 Chris AbellYusuf Hamied Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW UK.ORCID 0000-0001-9174-1987 Christina SpryYusuf Hamied Department of Chemistry University of Cambridge Lensfield Road Cambridge CB2 1EW UK.ORCID 0000-0002-8156-7070 University of Cambridge · GBAustralian National University · AUUniversity of Cape Town · ZAInserm · FRThe Francis Crick Institute · GBUniversidade de São Paulo · BR
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
The coenzyme A (CoA) biosynthesis pathway has attracted attention as a potential target for much-needed novel antimicrobial drugs, including for the treatment of tuberculosis (TB), the lethal disease caused by
Indexed as
Coenzyme ADrug DiscoveryEnzymesFragment-BasedTuberculosis
Identifiers
PMID38515507
PMCPMC10952327
OpenAlexW4319787878
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
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