ArticleFrontiers in neurology2024
Neurophysiological indices for split phenomena: correlation with age and sex and potential implications in amyotrophic lateral sclerosis.
Article in Frontiers in neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 4 citations in OpenAlex.
- Beyond ALS: split-hand syndrome in immune-mediated motor neuropathies.Journal of neurology · 2026Article
- Brain diffusion tensor imaging changes linked to the split hand phenomenon in amyotrophic lateral sclerosis.Scientific reports · 2025Article
- Reverse Split Hand as a Neurophysiological Hallmark of Spinal Muscular Atrophy.Journal of clinical medicine · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
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Abstract
Background: Split phenomena (SP) are characterized by patterns of differential muscle wasting and atrophy, which are highly prevalent in amyotrophic lateral sclerosis (ALS) patients. Several neurophysiological indicators, including the split-hand index (SHI), split-leg index (SLI), and split-elbow index (SEI), have been proposed to assess SP. Nevertheless, their cutoff values and the impact of age and sex on these measures remain unclear. Methods: We prospectively collected neurophysiological data from 300 healthy adult subjects. The following indices were measured from compound muscle action potentials (CMAPs): SHI [abductor pollicis brevis (APB Results: The median SHI was 10.4, with a median APB Conclusion: Our findings highlight the importance of age- and sex-adjusted normative data for SP indices, which could enhance their diagnostic accuracy and clinical utility in patients with ALS. The SL index appears to be the most reliable indicator, as it showed no significant association with age or sex.
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