Evidence map›Paper›PMID 38515105›Full record

ArticleThe international journal of behavioral nutrition and physical activity2024

Genetic confounding in the association of early motor development with childhood and adolescent exercise behavior.

Yahua Zi, Meike Bartels, Conor Dolan, Eco J C de Geus

Open access · goldAbstract readTwin Study
In one paragraph

Article in The international journal of behavioral nutrition and physical activity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Yahua ZiSchool of Exercise and Health, Shanghai University of Sport, Shanghai, China.ORCID 0000-0003-1481-1720
Meike BartelsDepartment of Biological Psychology, Vrije Universiteit Amsterdam, van der Boechorststraat 7, H541, Medical Faculty Building, Amsterdam, 1081 BT, Netherlands.ORCID 0000-0002-9667-7555
Conor DolanDepartment of Biological Psychology, Vrije Universiteit Amsterdam, van der Boechorststraat 7, H541, Medical Faculty Building, Amsterdam, 1081 BT, Netherlands.ORCID 0000-0002-2496-8492
Eco J C de GeusDepartment of Biological Psychology, Vrije Universiteit Amsterdam, van der Boechorststraat 7, H541, Medical Faculty Building, Amsterdam, 1081 BT, Netherlands. j.c.n.de.geus@vu.nl.ORCID 0000-0001-6022-2666
Amsterdam University Medical Centers · NLShanghai University of Sport · CNVrije Universiteit Amsterdam · NL

Funding

Determinants of Adolescent Exercise Behavior; towards Evidence-Based InterventionR01DK092127 · NIDDK · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HUDZIAK, JAMES J. · 2010 to 2014
$2.2M
EPA EP-C-15-001NIDDK NIH HHS R01 DK092127NIDDK NIH HHS R01 DK092127-04ZonMw 911-09-032
6 · The paper itself

Abstract

introductionEarly motor development has been found to be a predictor of exercise behavior in children and adolescents, but whether this reflects a causal effect or confounding by genetic or shared environmental factors remains to be established.

methodsFor 20,911 complete twin pairs from the Netherlands Twin Register a motor development score was obtained from maternal reports on the timing of five motor milestones. During a 12-year follow-up, subsamples of the mothers reported on the twins' ability to perform seven gross motor skills ability (N = 17,189 pairs), and weekly minutes of total metabolic equivalents of task (MET) spent on sports and exercise activities at age 7 (N = 3632 pairs), age 10 (N = 3735 pairs), age 12 (N = 7043 pairs), and age 14 (N = 3990 pairs). Multivariate phenotypic and genetic regression analyses were used to establish the predictive strength of the two motor development traits for future exercise behavior, the contribution of genetic and shared environmental factors to the variance in all traits, and the contribution of familial confounding to the phenotypic prediction.

resultsSignificant heritability (h

conclusionNo support was found for a direct causal effect in the association between rapid early motor development on future exercise behavior. In boys, early motor development appears to be an expression of the same genetic factors that underlie the heritability of childhood and early adolescent exercise behavior.

Indexed as

Adolescent BehaviorEnvironmentAdolescentChildExerciseFemaleHumansMaleMothersTwinsCausal modelingGross motor skillsMotor milestonesMultivariate genetic modelingTwin study

Identifiers

PMID38515105
PMCPMC10958919
OpenAlexW4393056466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.