Evidence map›Paper›PMID 38514862›Full record

ArticleActa pharmacologica Sinica2024

GPR41 deficiency aggravates type 1 diabetes in streptozotocin-treated mice by promoting dendritic cell maturation.

Jia-Hong Li, Ming Zhang, Zhao-di Zhang, Xiao-Hua Pan, Li-Long Pan, Jia Sun

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.9field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jia-Hong LiDepartment of Pediatric Laboratory, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Jiangnan University, Wuxi, 214023, China.
Ming ZhangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Zhao-di ZhangState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Xiao-Hua PanState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China.
Li-Long PanDepartment of Pediatric Laboratory, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Jiangnan University, Wuxi, 214023, China. llpan@jiangnan.edu.cn.
Jia SunState Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, 214122, China. jiasun@jiangnan.edu.cn.
Jiangnan University · CNState Key Laboratory of Food Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disturbances in intestinal immune homeostasis predispose susceptible individuals to type 1 diabetes (T1D). G-protein-coupled receptor 41 (GPR41) is a receptor for short-chain fatty acids (SCFAs) mainly produced by gut microbiota, which plays key roles in maintaining intestinal homeostasis. In this study, we investigated the role of GPR41 in the progression of T1D. In non-obese diabetic (NOD) mice, we found that aberrant reduction of GPR41 expression in the pancreas and colons was associated with the development of T1D. GPR41-deficient (Gpr41

Indexed as

Dendritic CellsDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Mice, Inbred NODMice, KnockoutReceptors, G-Protein-CoupledStreptozocinAnimalsFemaleGastrointestinal MicrobiomeInterferon-gammaMaleMiceMice, Inbred C57BLPancreasSTAT3 Transcription FactorGpcr41 protein, mouseInterferon-gammaReceptors, G-Protein-CoupledSocs3 protein, mouseSTAT3 Transcription FactorStreptozocinSuppressor of Cytokine Signaling 3 Proteindendritic cellsG protein-coupled receptor 41short-chain fatty acidsSOCS3STAT3type 1 diabetes

Identifiers

PMID38514862
PMCPMC11192896
OpenAlexW4393055149

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.