ArticleScientific reports2024
Alteration in kynurenine pathway metabolites in young women with autoimmune thyroiditis.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Salivary kynurenine pathway metabolites as potential non-invasive markers of glandular dysfunction in Sjögren's disease.Scientific reports · 2025Article
- Relationship between vitamin B6 intake and thyroid function in US adults: NHANES 2007-2012 results.PloS one · 2025Article
- Genetically predicted metabolites mediate the causal associations between autoimmune thyroiditis and immune cells.Frontiers in endocrinology · 2024Article
- Is the acquired hypothyroidism a risk factor for developing psychiatric disorders?Frontiers in psychiatry · 2024Review
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The kynurenine pathway (KP) of tryptophan degradation includes several compounds that reveal immunomodulatory properties. The present study aimed to investigate the alteration in KP metabolites in young women with autoimmune thyroiditis (AIT) and their associations with thyroid function. The thyroid function tests, antithyroid antibodies measurement and ultrasonography of the thyroid gland have been performed in 57 young women with AIT and 38 age-matched healthy controls. The serum levels of tryptophan, kynurenine (KYN) and its metabolites were determined, and the activity of KP enzymes was calculated indirectly as product-to-substrate ratios. KP was activated and dysregulated in AIT, along with significantly elevated levels of KYN and anthranilic acid (AA), at the expense of the reduction of kynurenic acid (KYNA), which was reflected by the increase in the AA/KYNA ratio (p < 0.001). In univariate and multiple regression analyses, peripheral deiodinase (SPINA-GD) activity in AIT was positively associated with KYNA, AA, and quinolinic acid (QA). The merger of AA, AA/KYNA ratio, QA and SPINA-GD exhibited the highest sensitivity and specificity to predict AIT (p < 0.001) in receiver operating characteristic (ROC) analysis. In conclusion, the serum KYN metabolite profile is dysregulated in young women with AIT and could serve as a new predictor of AIT risk.
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