Evidence map›Paper›PMID 38514273›Full record

ReviewTrends in biochemical sciences2024

Dilation of ion selectivity filters in cation channels.

Kate Huffer, Xiao-Feng Tan, Ana I Fernández-Mariño, Surbhi Dhingra, Kenton J Swartz

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in biochemical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Structure of the human KNature structural & molecular biology · 2025
    Article
  2. Article
  3. Structure of the human KbioRxiv : the preprint server for biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kate HufferMolecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Xiao-Feng TanMolecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Ana I Fernández-MariñoMolecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Surbhi DhingraMolecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
Kenton J SwartzMolecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: swartzk@ninds.nih.gov.
National Institutes of Health · US

Funding

Gating mechanisms and pharmacology of P2X receptor channelsZIANS003018 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SWARTZ, KENTON · 2009 to 2025
$13.8M
PROBING THE STRUCTURE AND FUNCTION OF POTASSIUM AND CALCIUM CHANNELSZ01NS002945 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI SWARTZ, KENTON J · 1997 to 2008
$1.9M
Gating mechanisms and pharmacology of P2X receptor channelsZ01NS003018 · NINDS · NEUROLOGICAL DISORDERS AND STROKE · PI SWARTZ, KENTON · 2007 to 2008
$996k
Intramural NIH HHS Z01 NS002945Intramural NIH HHS Z01 NS003018
6 · The paper itself

Abstract

Ion channels establish the voltage gradient across cellular membranes by providing aqueous pathways for ions to selectively diffuse down their concentration gradients. The selectivity of any given channel for its favored ions has conventionally been viewed as a stable property, and in many cation channels, it is determined by an ion-selectivity filter within the external end of the ion-permeation pathway. In several instances, including voltage-activated K

Indexed as

Ion ChannelsAnimalsCationsHumansIon Channel GatingCationsIon ChannelsATP-activated P2X receptor channelsion selectivityKv channelsTRP channels

Identifiers

PMID38514273
PMCPMC11069442
OpenAlexW4392976252

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.