Evidence map›Paper›PMID 38514181›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2024

Serotonin Signaling in Hippocampus during Initial Cocaine Abstinence Drives Persistent Drug Seeking.

Amy S Kohtz, Joshua Zhao, Gary Aston-Jones

Open access · greenAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Amy S KohtzBrain Health Institute, Rutgers University, Piscataway, New Jersey 08854 akohtz@umc.edu.
Joshua ZhaoBrain Health Institute, Rutgers University, Piscataway, New Jersey 08854.
Gary Aston-JonesBrain Health Institute, Rutgers University, Piscataway, New Jersey 08854.ORCID 0000-0002-5034-3816
Environmental and Occupational Health Sciences Institute · USRutgers Sexual and Reproductive Health and Rights · NLRutgers, The State University of New Jersey · US

Funding

The Impact of Stress and Craving on Return to Postpartum Cannabis UseU54DA016511 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Nathaniel Lee Baker · 2018 to 2026
$15.9M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
ROLE OF OREXIN IN COCAINE DEMAND AND ADDICTIONR01DA006214 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI ASTON-JONES, GARY S. · 1989 to 2024
$6.0M
Sex Differences in AddictionK99DA045758 · NIDA · RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL · PI KOHTZ, AMY · 2019 to 2020
$301k
NIDA NIH HHS K99 DA045758NIDA NIH HHS R01 DA006214NIDA NIH HHS U54 DA016511NIEHS NIH HHS T32 ES007148
6 · The paper itself

Abstract

The initiation of abstinence after chronic drug self-administration is stressful. Cocaine-seeking behavior on the first day of the absence of the expected drug (Extinction Day 1, ED1) is reduced by blocking 5-HT signaling in dorsal hippocampal cornu ammonis 1 (CA1) in both male and female rats. We hypothesized that the experience of ED1 can substantially influence later relapse behavior and that dorsal raphe (DR) serotonin (5-HT) input to CA1 may be involved. We inhibited 5-HT

Indexed as

CocaineDrug-Seeking BehaviorOxadiazolesSerotoninAnimalsCA1 Region, HippocampalCocaine-Related DisordersExtinction, PsychologicalFemaleHippocampusMalePiperazinesPyridinesRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT1BCocaineGR 127935N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamideOxadiazolesPiperazinesPyridinesReceptor, Serotonin, 5-HT1BSerotoninSerotonin Antagonistsaddictioncocaine seekingDREADDshippocampusserotoninsex differences

Identifiers

PMID38514181
PMCPMC11044100
OpenAlexW4393028805

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.