Evidence map›Paper›PMID 38514024›Full record

ArticleExperimental eye research2024

Photoreceptor deficits appear at eye opening in Rs1 mutant mouse models of X-linked retinoschisis.

Matthew J Tarchick, Craig Beight, Paul B Bonezzi, Neal S Peachey, Jordan M Renna

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Matthew J TarchickDepartment of Biology, University of Akron, Akron, OH, USA.
Craig BeightDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, 44195, USA.
Paul B BonezziDepartment of Biology, University of Akron, Akron, OH, USA.
Neal S PeacheyDepartment of Ophthalmic Research, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, 44195, USA; Research Service, VA Northeast Ohio Healthcare System, Cleveland, OH, 44106, USA; Department of Ophthalmology, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, 44106, USA.
Jordan M RennaDepartment of Biology, University of Akron, Akron, OH, USA. Electronic address: jrenna@uakron.edu.
University of Akron · USCleveland Clinic · US

Funding

RESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI Brian D Perkins · 2016 to 2026
$7.7M
Mechanisms of Vision Loss in X-Linked Juvenile RetinoschisisR01EY029796 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI MCANANY, JAMES JASON, PEACHEY, NEAL S. · 2019 to 2022
$1.9M
BLR&D Research Career Scientist AwardIK6BX005233 · VA · LOUIS STOKES CLEVELAND VA MEDICAL CENTER · PI NEAL S. PEACHEY · 2020 to 2026
–
BLRD VA IK6 BX005233NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY029796
6 · The paper itself

Abstract

X-linked retinoschisis (XLRS) is an early onset degenerative retinal disease characterized by cystic lesions in the middle layers of the retina. These structural changes are accompanied by a loss of visual acuity and decreased contrast sensitivity. XLRS is caused by mutations in the gene Rs1 which encodes the secreted protein Retinoschisin 1. Young Rs1-mutant mouse models develop key hallmarks of XLRS including intraretinal schisis and abnormal electroretinograms. The electroretinogram (ERG) comprises activity of multiple cellular generators, and it is not known how and when each of these is impacted in Rs1 mutant mice. Here we use an ex vivo ERG system and pharmacological blockade to determine how ERG components generated by photoreceptors, ON-bipolar, and Müller glial cells are impacted in Rs1 mutants and to determine the time course of these changes. We report that ERG abnormalities begin near eye-opening and that all ERG components are involved.

Indexed as

Cell Adhesion MoleculesDisease Models, AnimalElectroretinographyEye ProteinsRetinoschisisAnimalsEpendymoglial CellsMaleMiceMice, Inbred C57BLMutationPhotoreceptor Cells, VertebrateRetinal Bipolar CellsCell Adhesion MoleculesEye ProteinsRS1 protein, mouseElectroretinographyOuter retinaRetinal developmentRetinoschisinX-linked retinoschisis

Identifiers

PMID38514024
PMCPMC12817220
OpenAlexW4392948683

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.