Evidence map›Paper›PMID 38514013›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2024

Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop.

Kiran K Khush, James L Bernat, Richard N Pierson, Henry J Silverman, Brendan Parent, Alexandra K Glazier, Andrew B Adams, Jay A Fishman, Michael Gusmano, Wayne J Hawthorne and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Ethical Issues Involved in Solid Organ Xenotransplantation.Clinical anatomy (New York, N.Y.) · 2026
    Article
  5. Review
  6. Article
  7. Opinions on the Future of Clinical Pig Kidney Xenotransplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2024
    Review
  8. Review
  9. What's Hot in Transplant Infectious Diseases?Transplant infectious disease : an official journal of the Transplantation Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Kiran K KhushDivision of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA. Electronic address: kiran@stanford.edu.
James L BernatDepartment of Neurology, Dartmouth Geisel School of Medicine, Hanover, New Hampshire, USA.
Richard N PiersonDepartment of Surgery and Center for Transplantation Sciences, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Henry J SilvermanDepartment of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Brendan ParentDepartment of Population Health, New York University Grossman School of Medicine, New York, New York, USA.
Alexandra K GlazierNew England Donor Services, Waltham, Massachusetts, USA; School of Public Health, Brown University, Providence, Rhode Island, USA.
Andrew B AdamsDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
Jay A FishmanTransplant Infectious Disease and MGH Transplant Center, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Michael GusmanoCollege of Health, Lehigh University, Bethlehem, Pennsylvania, USA.
Wayne J HawthorneDepartment of Surgery, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia.
Mary E HomanDepartment of Theology and Ethics, CommonSpirit Health, Chicago, Illinois, USA.
Daniel J HurstDepartment of Family Medicine, Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA.
Stephen LathamInterdisciplinary Center for Bioethics, Yale University, New Haven, Connecticut, USA.
Chung-Gyu ParkDepartment of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, South Korea.
Karen J MaschkeThe Hastings Center, Garrison, New York, USA.
Muhammad M MohiuddinDepartment of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Robert A MontgomeryNYU Langone Transplant Institute, NYU Langone Health, New York, New York, USA.
Jonah OdimTransplantation Branch, Division of Allergy, Immunology, and Transplantation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Rebecca D PentzWinship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Bruno ReichartDepartment of Cardiac Surgery, Ludwig-Maximillian University, Munich, Germany.
Julian SavulescuCentre for Biomedical Ethics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Paul Root WolpeCenter for Ethics and Department of Medicine, Emory University, Atlanta, Georgia, USA.
Renee P WongHeart Failure and Arrhythmias Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kathleen N FentonAdvanced Technologies and Surgery Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, and Department of Bioethics, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.

Funding

Evidence Based Evaluation and Acceptance of Donor Hearts for TransplantationR01HL125303 · NHLBI · STANFORD UNIVERSITY · PI KHUSH, KIRAN KAUR · 2015 to 2019
$3.0M
A Noninvasive Integrated Genomic Approach for Early Cancer Detection and Risk Stratification after TransplantationR01CA229766 · NCI · STANFORD UNIVERSITY · PI ALIZADEH, ASH ARASH, KHUSH, KIRAN KAUR · 2019 to 2023
$3.0M
Informing Ethical Translation of Xenotransplantation Clinical TrialsR01TR003844 · NCATS · HASTINGS CENTER, INC. · PI GORDON, ELISA J, GUSMANO, MICHAEL KELLEY · 2021 to 2024
$1.9M
NCATS NIH HHS R01 TR003844NCI NIH HHS R01 CA229766NHLBI NIH HHS R01 HL125303
6 · The paper itself

Abstract

Xenotransplantation offers the potential to meet the critical need for heart and lung transplantation presently constrained by the current human donor organ supply. Much was learned over the past decades regarding gene editing to prevent the immune activation and inflammation that cause early organ injury, and strategies for maintenance of immunosuppression to promote longer-term xenograft survival. However, many scientific questions remain regarding further requirements for genetic modification of donor organs, appropriate contexts for xenotransplantation research (including nonhuman primates, recently deceased humans, and living human recipients), and risk of xenozoonotic disease transmission. Related ethical questions include the appropriate selection of clinical trial participants, challenges with obtaining informed consent, animal rights and welfare considerations, and cost. Research involving recently deceased humans has also emerged as a potentially novel way to understand how xeno-organs will impact the human body. Clinical xenotransplantation and research involving decedents also raise ethical questions and will require consensus regarding regulatory oversight and protocol review. These considerations and the related opportunities for xenotransplantation research were discussed in a workshop sponsored by the National Heart, Lung, and Blood Institute, and are summarized in this meeting report.

Indexed as

Heart TransplantationLung TransplantationTransplantation, HeterologousAnimalsBiomedical ResearchHumansNational Heart, Lung, and Blood Institute (U.S.)Tissue DonorsUnited Statesdonorsethicsresearchxenotransplantation

Identifiers

PMID38514013
PMCPMC11144553

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.