Evidence map›Paper›PMID 38513775›Full record

ReviewBiotechnology advances

A domain swapping strategy to create modular transcriptional regulators for novel topology in genetic network.

Clement T Y Chan, Vincenzo Kennedy, Sahaj Kinshuk

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biotechnology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Clement T Y ChanDepartment of Biomedical Engineering, University of North Texas, TX 76207, USA; BioDiscovery Institute, University of North Texas, TX 76207, USA. Electronic address: tyclementchan2@gmail.com.
Vincenzo KennedyDepartment of Biomedical Engineering, University of North Texas, TX 76207, USA.
Sahaj KinshukDepartment of Biomedical Engineering, University of North Texas, TX 76207, USA.
University of North Texas · US

Funding

Development of Genetic Sensors and Circuits for Creating Novel Cellular BehaviorsR35GM142421 · NIGMS · UNIVERSITY OF NORTH TEXAS · PI CHAN, TSZ YAN CLEMENT · 2021 to 2025
$1.8M
Design and construct modular transcriptional repressors to facilitate the development of living diagnosticsR15GM135813 · NIGMS · UNIVERSITY OF NORTH TEXAS · PI CHAN, TSZ YAN CLEMENT · 2021 to 2021
$392k
NIGMS NIH HHS R15 GM135813NIGMS NIH HHS R35 GM142421
6 · The paper itself

Abstract

Transcriptional regulators generate connections between biological signals and genetic outputs. They are used robustly for sensing input signals in building genetic circuits. However, each regulator can only generate a fixed connection, which generates constraints in linking multiple signals for more complex processes. Recent studies discovered that a domain swapping strategy can be applied to various regulator families to create modular regulators for new signal-output connections, significantly broadening possibilities in circuit design. Here we review the development of this emerging strategy, the use of resulting modular regulators for creating novel genetic response behaviors, and current limitations and solutions for further advancing the design of modular regulators.

Indexed as

Gene Regulatory NetworksDomain swappingGenetic circuit designProtein engineeringTranscriptional regulator

Identifiers

PMID38513775
PMCPMC11135624
OpenAlexW4392946779

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.