Evidence map›Paper›PMID 38513611›Full record

ArticleInfluenza and other respiratory viruses2024

Changes in Viral Dynamics Following the Legal Relaxation of COVID-19 Mitigation Measures in Japan From Children to Adults: A Single Center Study, 2020-2023.

Yosuke Hirotsu, Yuki Nagakubo, Makoto Maejima, Masahiro Shibusawa, Kazuhiro Hosaka, Hitomi Sueki, Hitoshi Mochizuki, Masao Omata

Open access · goldAbstract read
In one paragraph

Article in Influenza and other respiratory viruses, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Human adenovirus in Taiwan, 2019-2023.Archives of virology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Yosuke HirotsuGenome Analysis Center, Yamanashi Central Hospital, Kofu, Yamanashi, Japan.ORCID 0000-0002-8002-834X
Yuki NagakuboGenome Analysis Center, Yamanashi Central Hospital, Kofu, Yamanashi, Japan.
Makoto MaejimaDivision of Microbiology in Clinical Laboratory, Yamanashi Central Hospital, Kofu, Yamanashi, Japan.
Masahiro ShibusawaDivision of Microbiology in Clinical Laboratory, Yamanashi Central Hospital, Kofu, Yamanashi, Japan.
Kazuhiro HosakaDivision of Microbiology in Clinical Laboratory, Yamanashi Central Hospital, Kofu, Yamanashi, Japan.
Hitomi SuekiDivision of Microbiology in Clinical Laboratory, Yamanashi Central Hospital, Kofu, Yamanashi, Japan.
Hitoshi MochizukiGenome Analysis Center, Yamanashi Central Hospital, Kofu, Yamanashi, Japan.
Masao OmataDepartment of Gastroenterology, Yamanashi Central Hospital, Kofu, Yamanashi, Japan.
Yamanashi Prefectural Central Hospital · JP

Funding

Grant-in-Aid for the Genome Research Project from Yamanashi PrefectureJapan Society for the Promotion of Science 20H03668Japan Society for the Promotion of Science 23H02955Japan Society for the Promotion of Science JP18K16292Kato Memorial Bioscience FoundationTakeda Medical Research FoundationUehara Memorial FoundationYasuda Memorial Medical Foundation
6 · The paper itself

Abstract

introductionRespiratory infections are an ongoing global health challenge. The COVID-19 pandemic triggered global nonpharmacological measures that reshaped public health. In Japan, the shift from legal to individual discretion in pandemic management started on May 8, 2023. However, it still unknown how the relaxation of measures affects respiratory pathogens across age groups.

methodsWe collected 16,946 samples from 13,526 patients between February 2020 and September 2023, analyzing the circulating respiratory pathogen dynamics using FilmArray respiratory panel.

resultsOur analysis revealed significant increases in the positivity rates of respiratory pathogens across multiple age groups after relaxation. The pathogens including adenovirus, Bordetella pertussis, parainfluenza 2 and parainfluenza 4 showed increased positivity predominantly in children aged under 10 years. Conversely, some pathogens including human metapneumovirus, rhinovirus/enterovirus, and respiratory virus (RSV) increased in broad range of age groups. SARS-CoV-2 positivity rates decreased in children under 10 years but increased in those aged over 60 years. DISCUSSION: Age-stratified analysis reveals a dynamic pattern of circulating pathogen in each age group after relaxation measures. This study provides essential epidemiologic data that can guide strategies to protect different age groups and effectively respond to respiratory infections in post-COVID-19 era.

Indexed as

COVID-19Paramyxoviridae InfectionsRespiratory Tract InfectionsVirusesAdultAgedChildHumansJapanMiddle AgedPandemicsRhinovirusSARS-CoV-2COVID‐19enterovirusinfluenzarhinovirusRSV

Identifiers

PMID38513611
PMCPMC10957242
OpenAlexW4393029388

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.