Evidence map›Paper›PMID 38513272›Full record

ArticleInflammatory bowel diseases2024

Patient Perspectives of Bowel Urgency and Bowel Urgency-Related Accidents in Ulcerative Colitis and Crohn's Disease.

Vipul Jairath, Theresa Hunter Gibble, Alison Potts Bleakman, Kaitlin Chatterton, Paolo Medrano, Megan McLafferty, Brittany Klooster, Sonal Saxena, Richard Moses

Open access · hybridAbstract read
In one paragraph

Article in Inflammatory bowel diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Vipul JairathDivision of Gastroenterology, Department of Medicine, Western University, London, Ontario, OX3 9DU, Canada.ORCID 0000-0001-8603-898X
Theresa Hunter GibbleEli Lilly and Company, Indianapolis, IN, USA.ORCID 0000-0001-8412-9175
Alison Potts BleakmanEli Lilly and Company, Indianapolis, IN, USA.
Kaitlin ChattertonPatient-Centered Outcomes, Adelphi Values, Boston, Massachusetts, USA.
Paolo MedranoPatient-Centered Outcomes, Adelphi Values, Boston, Massachusetts, USA.
Megan McLaffertyPatient-Centered Outcomes, Adelphi Values, Boston, Massachusetts, USA.
Brittany KloosterPatient-Centered Outcomes, Adelphi Values, Boston, Massachusetts, USA.
Sonal SaxenaEli Lilly and Company, Indianapolis, IN, USA.
Richard MosesEli Lilly and Company, Indianapolis, IN, USA.
Eli Lilly (United States) · USPatient-Centered Outcomes Research Institute · USWestern University · CA

Funding

Eli Lilly and Company
6 · The paper itself

Abstract

backgroundBowel urgency is bothersome in patients with ulcerative colitis (UC) or Crohn's disease (CD) and impacts their well-being but remains underappreciated in clinical trials and during patient-healthcare provider interactions. This study explored the experiences of bowel urgency and bowel urgency-related accidents to identify the concepts most relevant and important to patients.

methodsAdults with a diagnosis of moderate-to-severe UC or CD for ≥6 months and experience of bowel urgency in the past 6 months were included. Qualitative, semi-structured interviews were conducted via telephonic/Web-enabled teleconference. Interview transcripts were coded and analyzed in ATLAS.ti 9 using a systematic thematic analysis.

resultsIn total, 30 participants with UC or CD (n = 15 each) (mean age 52 and 50 years, respectively) participated in the interviews. The majority of participants were receiving biologic and/or conventional therapy (80% and 87%, respectively). Most participants with UC (87%) and all with CD experienced bowel urgency-related accidents. The most frequently reported symptoms co-occurring with bowel urgency were abdominal pain, fatigue, and abdominal cramping. Abdominal pain and abdominal cramping were the most bothersome co-occurring symptoms of bowel urgency and bowel urgency-related accidents. In both groups, participants reported decreased frequency of bowel urgency and not wanting to experience bowel urgency-related accidents at all as a meaningful improvement.

conclusionsParticipants with UC or CD expressed bowel urgency and bowel urgency-related accidents to be bothersome and impactful on their daily lives despite use of biologic and/or conventional therapy. These findings underscore the need for development of patient-reported outcome measures to assess bowel urgency in clinical settings.

Indexed as

Colitis, UlcerativeCrohn DiseaseAbdominal PainAdultAgedFemaleHumansMaleMiddle AgedQualitative ResearchQuality of LifeSeverity of Illness Indexbowel urgencyCrohn’s diseasepatient-reported outcomesulcerative colitis

Identifiers

PMID38513272
PMCPMC11447055
OpenAlexW4393028224

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.