Evidence map›Paper›PMID 38513106›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker.

Ruofan Chen, Hendrik Glauninger, Darren N Kahan, Julia Shangguan, Joseph R Sachleben, Joshua A Riback, D Allan Drummond, Tobin R Sosnick

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Biomolecular Condensates Dictate the Folding Landscape of Proteins.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Client-scaffold interactions suppress aggregation of a client protein in model condensates.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Heterogeneous folding landscapes and predetermined breaking points within a protein family.Protein science : a publication of the Protein Society · 2024
    Article
  10. A coarse-grained model for disordered and multi-domain proteins.Protein science : a publication of the Protein Society · 2024
    Article
  11. Spontaneous assembly of condensate networks during the demixing of structured fluids.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Atomic resolution map of the solvent interactions driving SOD1 unfolding in CAPRIN1 condensates.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  13. Article
  14. HDX-MS finds that partial unfolding with sequential domain activation controls condensation of a cellular stress marker.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ruofan ChenPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637.
Hendrik GlauningerDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8989-0016
Darren N KahanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-8245-3489
Julia ShangguanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.
Joseph R SachlebenDivision of Biological Sciences, University of Chicago, Chicago, IL 60637.
Joshua A RibackDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.
D Allan DrummondDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637.ORCID 0000-0001-7018-7059
Tobin R SosnickPritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637.ORCID 0000-0002-2871-7244
Baylor College of Medicine · US

Funding

Molecular And Cellular Biology Training ProgramT32GM007183 · NIGMS · UNIVERSITY OF CHICAGO · PI GLICK, BENJAMIN S, RICE, PHOEBE A · 1985 to 2021
$23.9M
Kinetic studies of protein foldingR01GM055694 · NIGMS · UNIVERSITY OF CHICAGO · PI SOSNICK, TOBIN R · 2001 to 2022
$7.6M
Medical Scientist National Research Service AwardT32GM150375 · NIGMS · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2023 to 2026
$5.5M
Function and Regulation of Stress-Induced Adaptive CondensatesR35GM144278 · NIGMS · UNIVERSITY OF CHICAGO · PI David Allan Drummond · 2022 to 2026
$2.6M
Studies of the function of membrane and soluble proteins and their biophysical properties.R35GM148233 · NIGMS · UNIVERSITY OF CHICAGO · PI Tobin R Sosnick · 2023 to 2026
$2.1M
Determining the molecular basis of adaptive stress-triggered protein phase separationR01GM126547 · NIGMS · UNIVERSITY OF CHICAGO · PI DRUMMOND, DAVID ALLAN, SOSNICK, TOBIN R · 2018 to 2021
$1.6M
Signatures of interaction-driven selection on low-complexity sequencesR01GM127406 · NIGMS · UNIVERSITY OF CHICAGO · PI DRUMMOND, DAVID ALLAN · 2018 to 2021
$1.1M
Understanding mRNA Condensation and Its Role in Translational Control during StressF30ES032665 · NIEHS · UNIVERSITY OF CHICAGO · PI GLAUNINGER, HENDRIK · 2021 to 2025
$264k
FOLDING OF AN ALPHA-HELICAL COILED COILR29GM055694 · NIGMS · UNIVERSITY OF CHICAGO · PI SOSNICK, TOBIN R · 1996 to 2000
$107k
NIEHS NIH HHS F30 ES032665NIGMS NIH HHS R01 GM055694NIGMS NIH HHS R01 GM126547NIGMS NIH HHS R01 GM127406NIGMS NIH HHS R29 GM055694NIGMS NIH HHS R35 GM144278NIGMS NIH HHS R35 GM148233NIGMS NIH HHS T32 GM007183NIGMS NIH HHS T32 GM150375
6 · The paper itself

Abstract

Eukaryotic cells form condensates to sense and adapt to their environment [S. F. Banani, H. O. Lee, A. A. Hyman, M. K. Rosen,

Indexed as

Heat-Shock ProteinsPoly(A)-Binding ProteinsDeuterium Exchange MeasurementHeat-Shock ResponseTemperatureThermodynamicsHeat-Shock ProteinsPoly(A)-Binding Proteinscondensatehydrogen exchangemass spectrometryPab1phase separation

Identifiers

PMID38513106
PMCPMC10990091
OpenAlexW4393032795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.