Evidence map›Paper›PMID 38512882›Full record

ArticlePloS one2024

mTORC1 is required for differentiation of germline stem cells in the Drosophila melanogaster testis.

Marie Clémot, Cecilia D'Alterio, Alexa C Kwang, D Leanne Jones

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Evidence that injury can causebioRxiv : the preprint server for biology · 2026
    Article
  4. Metabolic Regulation in the Maintenance ofInternational journal of molecular sciences · 2026
    Review
  5. Article
  6. Article
  7. Stage-resolved transcriptomic profiling ofFrontiers in insect science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Marie ClémotDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States of America.ORCID 0000-0003-4992-1524
Cecilia D'AlterioDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States of America.
Alexa C KwangDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States of America.ORCID 0000-0003-3733-586X
D Leanne JonesDepartment of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, United States of America.ORCID 0000-0001-5721-6310
University of California, Los Angeles · US

Funding

Metabolic regulation of stem cell behavior and longevityR01AG040288 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, DANA LEANNE, WALKER, DAVID W · 2012 to 2016
$3.0M
Lipid mediated regulation of stem cell behavior and tissue homeostasisR01GM135767 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JONES, DANA LEANNE · 2020 to 2023
$1.8M
New tools for investigating mitochondrial dynamics in stem cells during agingR21AG052732 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JONES, DANA LEANNE · 2016 to 2017
$424k
NIA NIH HHS R01 AG040288NIA NIH HHS R21 AG052732NIGMS NIH HHS R01 GM135767
6 · The paper itself

Abstract

Metabolism participates in the control of stem cell function and subsequent maintenance of tissue homeostasis. How this is achieved in the context of adult stem cell niches in coordination with other local and intrinsic signaling cues is not completely understood. The Target of Rapamycin (TOR) pathway is a master regulator of metabolism and plays essential roles in stem cell maintenance and differentiation. In the Drosophila male germline, mTORC1 is active in germline stem cells (GSCs) and early germ cells. Targeted RNAi-mediated downregulation of mTor in early germ cells causes a block and/or a delay in differentiation, resulting in an accumulation of germ cells with GSC-like features. These early germ cells also contain unusually large and dysfunctional autolysosomes. In addition, downregulation of mTor in adult male GSCs and early germ cells causes non-autonomous activation of mTORC1 in neighboring cyst cells, which correlates with a disruption in the coordination of germline and somatic differentiation. Our study identifies a previously uncharacterized role of the TOR pathway in regulating male germline differentiation.

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsCell DifferentiationDrosophilaGerm CellsMaleMechanistic Target of Rapamycin Complex 1Stem CellsTestisTOR Serine-Threonine KinasesDrosophila ProteinsMechanistic Target of Rapamycin Complex 1TOR Serine-Threonine Kinases

Identifiers

PMID38512882
PMCPMC10956854
OpenAlexW4393028887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.