Evidence map›Paper›PMID 38512723›Full record

ArticleeLife2024

Targeting host deoxycytidine kinase mitigates

Volker Winstel, Evan R Abt, Thuc M Le, Caius G Radu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Drug Repurposing: An Emerging Strategy inJournal of microbiology and biotechnology · 2025
    Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

Volker WinstelResearch Group Pathogenesis of Bacterial Infections; TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Hannover Medical School and the Helmholtz Centre for Infection Research, Hannover, Germany.ORCID https://orcid.org/0000-0002-3248-2572
Evan R AbtDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, United States.
Thuc M LeDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, United States.
Caius G RaduDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, United States.
University of California, Los Angeles · US

Funding

UCLA Tumor Immunology Training ProgramT32CA009120 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Steven M. Dubinett, MICHAEL A TEITELL · 1985 to 2026
$10.3M
Targeting KRAS and adenosine mediated immunosuppression in pancreatic cancerR01CA260678 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONAHUE, TIMOTHY R, RADU, CAIUS GABRIEL · 2021 to 2025
$3.0M
IMMUNE RESPONSE IN-VITRO H-2 (IR) LOCUS FUNCTIONR01CA025052 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NIEDERHUBER, JOHN E. · 1985 to 1986
–
NCI NIH HHS R01 CA260678NCI NIH HHS T32 CA009120NIH HHS 1R01CA25052901A1NIH HHS 1R01CA260678-01
6 · The paper itself

Abstract

Host-directed therapy (HDT) is an emerging approach to overcome antimicrobial resistance in pathogenic microorganisms. Specifically, HDT targets host-encoded factors required for pathogen replication and survival without interfering with microbial growth or metabolism, thereby eliminating the risk of resistance development. By applying HDT and a drug repurposing approach, we demonstrate that (

Indexed as

Anti-Infective AgentsStaphylococcal InfectionsAbscessAnimalsDeoxycytidine KinaseHumansMammalsStaphylococcus aureusAnti-Infective AgentsDeoxycytidine Kinaseapoptosisinfectious diseasemacrophagesmicrobiologyStaphylococcus aureus

Identifiers

PMID38512723
PMCPMC10957174
OpenAlexW4387541111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.