ArticleLa Radiologia medica2024
Pancreatic cancer detection with dual-energy CT: diagnostic performance of 40 keV and 70 keV virtual monoenergetic images.
Article in La Radiologia medica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Rim enhancement on imaging of pancreatic ductal adenocarcinoma: systematic review and meta-analysis of biological and prognostic values.La Radiologia medica · 2026Pooled it
- What you don't see matters: dual-energy CT in emergency radiology.Japanese journal of radiology · 2026Review
- Feasibility of single-phase DECT as an alternative to triple-phase CT for imaging-defined risk factors assessment in neuroblastoma for dose reduction.European journal of radiology open · 2026Article
- Multi-institutional study for comparison of detectability of hypovascular liver metastases between 70- and 40-keV images: DELMIO study.Abdominal radiology (New York) · 2026Article
- Tumour mutation burden drives survival outcomes in pancreatic ductal adenocarcinoma and enables noninvasive prediction via dual-layer spectral CT.Insights into imaging · 2026Article
- Temporal bone dual-layer detector dual-energy computed tomography for identifying cholesteatoma.European radiology · 2026Article
- Intratumoral calcifications in pancreatic neoplasms on unenhanced CT: frequency and diagnostic implications.La Radiologia medica · 2026Article
- Pancreatic Cystic Lesions: From Basic Knowledge to Recent Guidelines.Journal of clinical medicine · 2026Review
- Spectral Computed Tomography Diagnosis of Inflammatory Bowel Disease with Neodymium-Hyaluronic Acid Nanoparticles.Biomaterials research · 2026Article
- Feasibility of Ultra-Dilute Iodine Contrast Agent in Dual-Layer Spectral CT for Pulmonary Artery ImagingCurrent medical imaging · 2026Article
- Novel silicon-based material decomposition images in diagnosis of pancreatic ductal adenocarcinoma: comparison with iodine-based and 50-keV virtual monoenergetic images.Japanese journal of radiology · 2026Article
- Evaluation of a dual-energy computed tomography parameter -radiomics combined model for solitary pulmonary nodules.Frontiers in oncology · 2026Article
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare the diagnostic performance of 40 keV and 70 keV virtual monoenergetic images (VMIs) generated from dual-energy CT in the detection of pancreatic cancer.
methodsThis retrospective study included patients who underwent pancreatic protocol dual-energy CT from January 2019 to August 2022. Four radiologists (1-11 years of experience), who were blinded to the final diagnosis, independently and randomly interpreted 40 keV and 70 keV VMIs and graded the presence or absence of pancreatic cancer. For each image set (40 keV and 70 keV VMIs), the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were calculated. The diagnostic performance of each image set was compared using generalized estimating equations.
resultsOverall, 137 patients (median age, 71 years; interquartile range, 63-78 years; 77 men) were included. Among them, 62 patients (45%) had pathologically proven pancreatic cancer. The 40 keV VMIs had higher specificity (75% vs. 67%; P < .001), PPV (76% vs. 71%; P < .001), and accuracy (85% vs. 81%; P = .001) than the 70 keV VMIs. On the contrary, 40 keV VMIs had lower sensitivity (96% vs. 98%; P = .02) and NPV (96% vs. 98%; P = .004) than 70 keV VMIs. However, the diagnostic confidence in patients with (P < .001) and without (P = .001) pancreatic cancer was improved in 40 keV VMIs than in 70 keV VMIs.
conclusionsThe 40 keV VMIs showed better diagnostic performance in diagnosing pancreatic cancer than the 70 keV VMIs, along with higher reader confidence.
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