Evidence map›Paper›PMID 38512507›Full record

SynthesisHernia : the journal of hernias and abdominal wall surgery2024

The use of poly-4-hydroxybutyrate (P4HB, Phasix™) mesh in ventral hernia repair: a systematic review and meta-analysis.

Daniel H Tran, Charles Rubarth, Steven G Leeds, Luke Fair, Titus McGowan, Sudha Ramakrishnan, Rehma Shabbir, Gerald Ogola, Marc A Ward, Bola Aladegbami

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Hernia : the journal of hernias and abdominal wall surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Mesh removal and ventral hernia repair with long-term absorbable mesh in case of mesh infection.Hernia : the journal of hernias and abdominal wall surgery · 2025
    Article
  8. Review
  9. Clinical outcomes of oncologic hernia repair using Poly-4-Hydroxybutyrate (P4HB) mesh.Hernia : the journal of hernias and abdominal wall surgery · 2025
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel H TranTexas A&M College of Medicine, Bryan, TX, USA.ORCID 0009-0000-8782-0375
Charles RubarthResearch Institute, Baylor Scott and White Health, Dallas, TX, USA.
Steven G LeedsTexas A&M College of Medicine, Bryan, TX, USA.
Luke FairResearch Institute, Baylor Scott and White Health, Dallas, TX, USA.
Titus McGowanResearch Institute, Baylor Scott and White Health, Dallas, TX, USA.
Sudha RamakrishnanResearch Institute, Baylor Scott and White Health, Dallas, TX, USA.
Rehma ShabbirResearch Institute, Baylor Scott and White Health, Dallas, TX, USA.
Gerald OgolaResearch Institute, Baylor Scott and White Health, Dallas, TX, USA.
Marc A WardDepartment of Minimally Invasive Surgery, Baylor University Medical Center, Dallas, TX, USA.
Bola AladegbamiTexas A&M College of Medicine, Bryan, TX, USA. bola.aladegbami@bswhealth.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PURPOSE/

backgroundDespite the growing use of bioabsorbable mesh in ventral hernia repairs (VHR), the evidence of its impact on patient outcomes remains limited. This study aims to investigate the efficacy and safety profile of poly-4-hydroxybutyrate (P4HB) mesh for ventral hernia repair through a systematic review and meta-analysis.

methodsA literature search of five databases (PubMed, Embase, Ovid, Medline, and Google Scholar) produced a list of publications that analyzed the use of P4HB mesh in ventral hernia repair in both clean and contaminated cases. The primary postoperative outcomes of hernia recurrence, surgical site infections (SSI), and any complications were analyzed through a pooled meta-analysis.

resultsIn our systematic review, 21 studies met the inclusion criteria with a total of 1858 patients (933 males and 925 females) and an average age of 56.8 years. The median follow-up ranged from 1.6 to 62.3 months. In our meta-analysis, the use of P4HB mesh in VHR in proportion of events demonstrated a recurrence rate of 9% [6%; 15%], SSI of 10% [6%; 16%] and 35% [9%; 42%] for rate of any complications. Sub-meta-analysis restricted to studies with follow up > 18 months continues to show low rates of recurrence of 9% (95%CI, 4-17%), SSI of 9% (95%CI, 4-16%), and 31% (95%CI, 23-41%) for any complications.

conclusionOur study demonstrates that the use of P4HB mesh is both safe and effective in ventral hernia repairs. When further analyzed past 18 months, the time where P4HB mesh fully resorbs, the rates of hernia recurrence, SSI, and any complications remain low of upwards of 5 years and comparable to the rates seen in synthetic and biologics in similar patient populations.

Indexed as

Hernia, VentralHerniorrhaphyPolyestersRecurrenceSurgical MeshAbsorbable ImplantsHumansHydroxybutyratesPostoperative ComplicationsSurgical Wound InfectionHydroxybutyratespoly(4-hydroxybutanoate)PolyestersBioabsorbable meshHerniaPhasixPoly-4-hydroxybutyrate

Identifiers

PMID38512507

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.