ArticleIntensive care medicine2024
Invasive Fungal Diseases in Adult Patients in Intensive Care Unit (FUNDICU): 2024 consensus definitions from ESGCIP, EFISG, ESICM, ECMM, MSGERC, ISAC, and ISHAM.
Open access · hybridAbstract readConsensus Statement
In one paragraph
Article in Intensive care medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 6 pooled it
57.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
126 citing papers in PubMed, 6 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Antifungal therapy for newborn infants with invasive fungal infection.The Cochrane database of systematic reviews · 2026Pooled it
- Incidence, mortality and risk factors of invasive pulmonary aspergillosis in critically ill patients during the COVID-19 era: a global systematic review and meta-analysis.Annals of clinical microbiology and antimicrobials · 2026Pooled it
- [S3 guideline on sepsis-prevention, diagnosis, therapy, and follow-up care-update 2025].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2025Guideline
- Guideline
- Guideline
- Brazilian guidelines for the diagnosis and treatment of candidemia and invasive candidiasis in adults and children.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesGuideline
- Interpretable Machine Learning Model for Fungal Infection Prediction: A Real-World Study.Health care science · 2026Article
- Invasive pulmonary aspergillosis caused by a rare species ofJAC-antimicrobial resistance · 2026Article
- Early Bedside Risk Stratification in ICU Patients with Suspected Invasive Pulmonary Aspergillosis: A Minimalist Clinical Decision Support Model.Journal of fungi (Basel, Switzerland) · 2026Article
- Invasive pulmonary aspergillosis following mild Covid-19 in an autologous hematopoietic stem cell transplant recipient: A case report.Medical mycology case reports · 2026Article
- Unclassifiable Invasive Pulmonary Aspergillosis in the Intensive Care Unit: Insights From a Multicenter, Retrospective Cohort Study in France (2022-2024).Open forum infectious diseases · 2026Article
- Therapeutic Failure in Invasive Fungal Infections: Beyond Antifungal Resistance-A Narrative Review.Journal of fungi (Basel, Switzerland) · 2026Review
- Population pharmacokinetics, target attainment and individualized dosing of isavuconazole in critically ill adults receiving extracorporeal membrane oxygenation.JAC-antimicrobial resistance · 2026Article
- Research trends in COPD-associated invasive pulmonary aspergillosis over the past two decades: a bibliometric and topic modelling analysis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Review
- Diagnostic Failure in Invasive Fungal Infections: Causes, Clinical Consequences, and Mitigation Strategies.Journal of fungi (Basel, Switzerland) · 2026Review
- Diagnostic criteria for invasive pulmonary aspergillosis in COPD patients.American journal of respiratory and critical care medicine · 2026Article
- Decoding candidemia in critically ill patients: unsupervised clustering identifies three unique phenotypes.Critical care (London, England) · 2026Article
- Pathogen-specific epidemiology and clinical trajectories of fungal infections after kidney transplantation: a prospective multicenter cohort study.BMC infectious diseases · 2026Article
- Clinical characteristics and outcomes of invasive fungal infections in critically ill patients with liver cirrhosis.BMC infectious diseases · 2026Article
- Surgical therapy for pulmonary aspergillomas and mucormycosis: A 15-year experience from a single clinical center.JTCVS open · 2026Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
47 authors at 20 institutions in 16 countries.
Matteo BassettiDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy. matteo.bassetti@hsanmartino.it.ORCID 0000-0002-0145-9740
Daniele R GiacobbeDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Christina Agvald-OhmanAnaesthesiology and Intensive Care, Karolinska University Hospital Huddinge, Stockholm, Sweden.
Murat AkovaDepartment of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Ana Alastruey-IzquierdoMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Sevtap Arikan-AkdagliDepartment of Medical Microbiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey.
Elie AzoulayUniversité de Paris, Paris, France.
Stijn BlotDepartment of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
Oliver A CornelyDepartment I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Manuel Cuenca-EstrellaMycology Reference Laboratory, National Centre for Microbiology, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
Dylan W de LangeDepartment of Intensive Care Medicine, University Medical Center, University Utrecht, Utrecht, The Netherlands.
Francesco G De RosaDepartment of Medical Sciences, Infectious Diseases, University of Turin, Turin, Italy.
Jan J De WaeleDepartment of Critical Care Medicine, Ghent University Hospital, Ghent, Belgium.
George DimopoulosDepartment of Critical Care, University Hospital Attikon, Attikon Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Jose Garnacho-MonteroIntensive Care Unit, Virgen del Rocío University Hospital, Seville, Spain.
Martin HoeniglDivision of Infectious Diseases, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Souha S KanjDivision of Infectious Diseases, and Center for Infectious Diseases Research, American University of Beirut Medical Center, Beirut, Lebanon.
Philipp KoehlerDepartment I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD) and Excellence Center for Medical Mycology (ECMM), Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Bart J KullbergDepartment of Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
Frédéric LamothInstitute of Microbiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Cornelia Lass-FlörlInstitute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Johan MaertensUniversitair Ziekenhuis Leuven, Louvain, Belgium.
Ignacio Martin-LoechesDepartment of Intensive Care Medicine, Multidisciplinary Intensive Care Research Organization (MICRO), St James' Hospital, Dublin, Ireland.
Patricia MuñozClinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Garyphallia PoulakouThird Department of Internal Medicine, School of Medicine, Sotiria General Hospital, National and Kapodistrian University, Athens, Greece.
Jordi RelloClinical Research/Epidemiology in Pneumonia and Sepsis (CRIPS), Vall d'Hebron Institut of Research (VHIR), Barcelona, Spain.
Maurizio SanguinettiDipartimento di Scienze di Laboratorio E Infettivologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Fabio S TacconeDepartment of Intensive Care, Hôpital Universitaire de Bruxelles (HUB), Université Libre de Bruxelles (ULB), Brussels, Belgium.
Jean-François TimsitMedical and Infectious Diseases Intensive Care Unit, AP-HP, Bichat Claude Bernard University Hospital, Paris, France.
Antoni TorresDepartment of Pneumology, Hospital Clinic of Barcelona, Barcelona, Spain.
Jose A VazquezDepartment of Medicine/Division of Infectious Disease, Medical College of Georgia/Augusta University, Augusta, GA, USA.
Joost WautersMedical Intensive Care Unit, University Hospitals Leuven, Louvain, Belgium.
Erika AspergesInfectious Diseases Unit, IRCCS San Matteo, Pavia, Italy.
Andrea CortegianiDepartment of Precision Medicine in Medical, Surgical and Critical Care (Me.Pre.C.C.), University of Palermo, Palermo, Italy.
Cecilia GrecchiMalattie Infettive, Azienda Socio Sanitaria Territoriale (ASST) di Lodi, Lodi, Italy.
Ilias Karaiskos1st Department of Internal Medicine-Infectious Diseases, Hygeia General Hospital, Athens, Greece.
Clément Le BihanSaint Eloi Department of Anesthesiology and Critical Care Medicine, Montpellier University Health Care Center, Montpellier, France.
Toine MercierDepartment of Microbiology, Immunology and Transplantation, KU Leuven, Louvain, Belgium.
Klaus L MortensenDepartment of Medicine, Regional Hospital West Jutland, Herning, Denmark.
Maddalena PeghinInfectious and Tropical Diseases Unit, Department of Medicine and Surgery, University of Insubria-ASST-Sette Laghi, Varese, Italy.
Chiara RebuffiScientific Direction, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Sofia TejadaClinical Research/Epidemiology in Pneumonia and Sepsis (CRIPS), Vall d'Hebron Institut of Research (VHIR), Barcelona, Spain.
Antonio VenaDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Valentina ZuccaroInfectious Diseases Unit, IRCCS San Matteo, Pavia, Italy.
Luigia ScudellerResearch and Innovation Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Thierry CalandraService of Immunology and Allergy and Center of Human Immunology Lausanne, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Study Group for Infections in Critically Ill Patients of the European Society of Clinical Microbiology and Infectious Diseases (ESGCIP), the Fungal Infection Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EFISG), the European Society of Intensive Care Medicine (ESICM), the European Confederation of Medical Mycology (ECMM), the Mycoses Study Group Education and Research Consortium (MSGERC), the International Society of Antimicrobial Chemotherapy (ISAC), the International Society for Human and Animal Mycology (ISHAM), the Austrian Society for Medical Mycology (ÖGMM), the Italian Society of Anesthesia, Analgesia, Reanimation, and Intensive Care (SIAARTI), the Italian Society of Anti-Infective Therapy (SITA), and the FUNDICU Collaborators
Instituto de Salud Carlos III · ESOspedale Policlinico San Martino · ITHacettepe University · TRKU Leuven · BEPoliclinico San Matteo Fondazione · ITUniversity of Cologne · DEUniversity of Lausanne · CHAmerican University of Beirut Medical Center · LBAugusta University · USAzienda Ospedaliera Universitaria Policlinico "Paolo Giaccone" di Palermo · ITAzienda Socio Sanitaria Territoriale Lariana · ITAzienda USL di Bologna · ITGhent University Hospital · BEHospital Universitario Virgen del Rocío · ESHygeia Hospital · GRInnsbruck Medical University · ATInstitució Catalana de Recerca i Estudis Avançats · ESIstituto Giannina Gaslini · ITKarolinska University Hospital · SEMedical University of Graz · AT
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this document was to develop standardized research definitions of invasive fungal diseases (IFD) in non-neutropenic, adult patients without classical host factors for IFD, admitted to intensive care units (ICUs).
methodsAfter a systematic assessment of the diagnostic performance for IFD in the target population of already existing definitions and laboratory tests, consensus definitions were developed by a panel of experts using the RAND/UCLA appropriateness method.
resultsStandardized research definitions were developed for proven invasive candidiasis, probable deep-seated candidiasis, proven invasive aspergillosis, probable invasive pulmonary aspergillosis, and probable tracheobronchial aspergillosis. The limited evidence on the performance of existing definitions and laboratory tests for the diagnosis of IFD other than candidiasis and aspergillosis precluded the development of dedicated definitions, at least pending further data. The standardized definitions provided in the present document are aimed to speed-up the design, and increase the feasibility, of future comparative research studies.
Indexed as
AspergillosisCandidiasis, InvasiveInvasive Fungal InfectionsAdultHumansIntensive Care UnitsAspergillusCandidaConsensusDefinitionsDiagnosisIntensive care unitInvasive fungal diseasesResearch
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.