Evidence map›Paper›PMID 38511670›Full record

ReviewExpert review of proteomics2024

Proteomics applications in next generation induced pluripotent stem cell models.

Vyshnavi Manda, Jay Pavelka, Edward Lau

Abstract readReview
In one paragraph

Review in Expert review of proteomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vyshnavi MandaDepartment of Medicine, Division of Cardiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jay PavelkaDepartment of Medicine, Division of Cardiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Edward LauDepartment of Medicine, Division of Cardiology, University of Colorado School of Medicine, Aurora, Colorado, USA.

Funding

Multi-Omics Approach to Identify Cardiokines in Human iPSC ModelsR00HL144829 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LAU, EDWARD · 2020 to 2022
$733k
NHLBI NIH HHS R00 HL144829
6 · The paper itself

Abstract

introductionInduced pluripotent stem (iPS) cell technology has transformed biomedical research. New opportunities now exist to create new organoids, microtissues, and body-on-a-chip systems for basic biology investigations and clinical translations. AREAS COVERED: We discuss the utility of proteomics for attaining an unbiased view into protein expression changes during iPS cell differentiation, cell maturation, and tissue generation. The ability to discover cell-type specific protein markers during the differentiation and maturation of iPS-derived cells has led to new strategies to improve cell production yield and fidelity. In parallel, proteomic characterization of iPS-derived organoids is helping to realize the goal of bridging in vitro and in vivo systems. EXPERT OPINIONS: We discuss some current challenges of proteomics in iPS cell research and future directions, including the integration of proteomic and transcriptomic data for systems-level analysis.

Indexed as

Cell DifferentiationInduced Pluripotent Stem CellsProteomicsAnimalsHumansOrganoidsInduced pluripotent stem cellmass spectrometryorganoidsproteomicssecretome

Identifiers

PMID38511670
PMCPMC11065590

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.