ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024
Mechanisms of coronary sinus reducer for treatment of myocardial ischemia: in silico study.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
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Who cites it
10 citing papers in PubMed.
- A Poroelastic Computational Modeling Framework Coupling Left Ventricular Cardiac Mechanics and Myocardial Perfusion.International journal for numerical methods in biomedical engineering · 2026Article
- Hierarchy Aware CT-Driven Constrained Constructive Optimization: A Framework for Coronary Network Generation.Annals of biomedical engineering · 2026Article
- A multi-fractal vascular tree model for characterizing blood flow in cardiovascular system.Scientific reports · 2026Article
- Coronary Sinus Reduction for REDUCER-I Patients With Refractory Angina and Angiographically Nonobstructive Coronary Artery Disease.JACC. Advances · 2026Article
- Use of a Novel, Self-Expanding Coronary Sinus Reducer to Treat Symptomatic Epicardial and Microvascular Ischemic Heart Disease: Preclinical and First-in-Human Experience.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Coronary Sinus Reducer: History, Current Applications, and Future Perspectives.Reviews in cardiovascular medicine · 2025Review
- Focusing on microvascular function in heart failure with preserved ejection fraction.Heart failure reviews · 2025Review
- The Novel A-Flux Coronary Sinus Reducer Normalizes Coronary Microvascular Function in a Persistently Symptomatic Patient.JACC. Case reports · 2025Article
- Computer model coupling hemodynamics and oxygen transport in the coronary capillary network: Pulsatile vs. non-pulsatile analysis.Computer methods and programs in biomedicine · 2025Article
- Coronary Sinus Reducer Therapy for Refractory Angina and its Role in Modern Interventional Practice: A Contemporary Review.Interventional cardiology (London, England) · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The coronary sinus reducer (CSR) is an emerging medical device for treating patients with refractory angina, often associated with myocardial ischemia. Patients implanted with CSR have shown positive outcomes, but the underlying mechanisms are unclear. This study sought to understand the mechanisms of CSR by investigating its effects on coronary microcirculation hemodynamics that may help explain the therapy's efficacy. We applied a validated computer model of the coronary microcirculation to investigate how CSR affects hemodynamics under different degrees of coronary artery stenosis. With moderate coronary stenosis, an increase in capillary transit time (CTT) [up to 69% with near-complete coronary sinus (CS) occlusion] is the key change associated with CSR. Because capillaries in the microcirculation can still receive oxygenated blood from the upstream artery with moderate stenosis, the increase in CTT allows more time for the exchange of gases and nutrients, aiding tissue oxygenation. With severe coronary stenosis; however, the redistribution of blood draining from the nonischemic region to the ischemic region (up to 96% with near-complete CS occlusion) and the reduction in capillary flow heterogeneity are the key changes associated with CSR. Because blood draining from the nonischemic region is not completely devoid of O
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Registered trials
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