Evidence map›Paper›PMID 38511068›Full record

ReviewInternational journal of pharmaceutics: X2024

Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges.

Zhechen Fan, Haroon Iqbal, Jiang Ni, Naveed Ullah Khan, Shahla Irshad, Anam Razzaq, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ali A Shati, Jianping Zhou and 1 more

Abstract readReview
In one paragraph

Review in International journal of pharmaceutics: X, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhechen FanState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Haroon IqbalEye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou 325027, Zhejiang, China.
Jiang NiDepartment of Pharmacy, Affiliated Hospital of Jiangnan University, Wuxi 214000, China.
Naveed Ullah KhanDepartment of Pharmacy, Zhejiang University of Technology, Hangzhou 310000, China.
Shahla IrshadDepartment of Allied Health Sciences, Faculty of Health and Medical Sciences, Mirpur University of Science and Technology (MUST), Mirpur, Azad Jammu and Kashmir 10250, Pakistan.
Anam RazzaqCollege of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.
Mohammad Y AlfaifiKing Khalid University, Faculty of Science, Biology Department, Abha 9004, Saudi Arabia.
Serag Eldin I ElbehairiKing Khalid University, Faculty of Science, Biology Department, Abha 9004, Saudi Arabia.
Ali A ShatiKing Khalid University, Faculty of Science, Biology Department, Abha 9004, Saudi Arabia.
Jianping ZhouState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
Hao ChengState Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The clinical advancement of protein-based nanomedicine has revolutionized medical professionals' perspectives on cancer therapy. Protein-based nanoparticles have been exploited as attractive vehicles for cancer nanomedicine due to their unique properties derived from naturally biomacromolecules with superior biocompatibility and pharmaceutical features. Furthermore, the successful translation of Abraxane™ (paclitaxel-based albumin nanoparticles) into clinical application opened a new avenue for protein-based cancer nanomedicine. In this mini-review article, we demonstrate the rational design and recent progress of protein-based nanoparticles along with their applications in cancer diagnosis and therapy from recent literature. The current challenges and hurdles that hinder clinical application of protein-based nanoparticles are highlighted. Finally, future perspectives for translating protein-based nanoparticles into clinic are identified.

Indexed as

AlbuminFerritinProtein-drug conjugateProtein nanoparticlesProtein nanoreactor

Identifiers

PMID38511068
PMCPMC10951516

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.