Expression Profile of KRAS and p16 in Periampullary Cancer.

Mallika Tewari, Jyoti R Swain, Raghvendra R Mishra, Vinod K Dixit, H S Shukla

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Article in Indian journal of surgical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors at 1 institution in 1 country.

Mallika TewariDepartment of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P. 221005 India.ORCID 0000-0001-7005-9436

Jyoti R SwainDepartment of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P. 221005 India.

Raghvendra R MishraMedical Lab Technology, DDU Kaushal Kendra, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P. 221005 India.

Vinod K DixitDepartment Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P. 221005 India.

H S ShuklaDepartment of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, U.P. 221005 India.

Institute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activating point mutations in codons 12, 13, and 61 of the KRAS gene and loss of p16 expression, a tumor suppressor gene, are common genetic alterations in periampullary cancer (PAC). The present study explores expression profile of KRAS and p16 genes in PAC and its prognostic relevance. A total of 50 patients with PAC who underwent potentially curative pancreaticoduodenectomy were included in the study. Formalin-fixed, paraffin-embedded tissue samples were analyzed for point mutations in codons 12 and 13 of KRAS and codon 9 of p16 using polymerase chain reaction. KRAS mutation in codon 12/13 was found in 32 (64%) and loss of p16 expression in 36 (72%) cases. KRAS mutation was significantly associated with higher grade, higher pathological tumor (pT) stage, lymphovascular invasion (LVI), perineural invasion (PNI), and pathological lymph nodes (pN) involvement on univariate analysis. On multivariate analysis, significant association of KRAS remained with higher grade (

Indexed as

KRASp16/CDKN2A/INK4APeriampullary cancerPrognosisSurvival

Identifiers

PMID38511045

DOI10.1007/s13193-023-01819-4

PMCPMC10948726

OpenAlexW4386727962

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.