ArticleBrain & spine2024
Surgical complications of vagus nerve stimulation surgery: A 14-years single-center experience.
Article in Brain & spine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcutaneous auricular vagus nerve stimulation may improve cognitive deficits in neuropsychiatric diseases-a systematic review.Frontiers in aging neuroscience · 2026Pooled it
- Transcutaneous auricular vagus nerve stimulation paired with task-specific training for improving walking and balance in chronic stroke: a double-blind, randomised controlled feasibility trial.Journal of neuroengineering and rehabilitation · 2026Trial
- Feasibility and safety of same-day discharge after paediatric vagus nerve stimulator implantation for medically intractable epilepsy: a retrospective safety analysis.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Auricular Ultrasonic Vagus Nerve Stimulation: Effectiveness of Blinding and the Occurrence of Adverse Effects in People with Tinnitus.Brain sciences · 2026Article
- Early reduction in unplanned healthcare utilization following vagus nerve stimulation for pediatric epilepsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Article
- Transcutaneous auricular vagus nerve stimulation attenuates neuroinflammation in a mouse model of traumatic brain injury.The journal of trauma and acute care surgery · 2026Article
- Anesthetic Management of Patients for Vagal Nerve Stimulator Placement: A Narrative Review.Neuropsychiatric disease and treatment · 2026Review
- The Palliative Nature of Pediatric Epilepsy Surgery and Our Procedures.Pediatric neurosurgery · 2026Review
- Clinical experience implanting a miniature externally powered vagus nerve stimulator.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Hydrogel Adhesive Integrated-Microstructured Electrodes for Cuff-Free, Less-Invasive, and Stable Interface for Vagus Nerve Stimulation.Advanced healthcare materials · 2025Article
- How I do it: surgical techniques for vagus nerve stimulation in pediatric drug-resistant epilepsy.Acta neurochirurgica · 2025Article
- Complications and Mortality Rate of Vagus Nerve Stimulation for Drug-Resistant Epilepsy.Cureus · 2024Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Vagus nerve stimulation (VNS) is the most frequently used neuromodulation treatment for Drug-Resistant Epilepsy (DRE) patients. Complications of VNS surgery include surgical site infection and unilateral vocal cord paresis. Complication rates vary across studies. Research question: What is the safety profile of VNS related surgeries? Materials and methods: Retrospective cohort study using patient files of DRE-patients who had undergone primary implantation of a VNS-system, replacement of the VNS pulse generator, replacement of the lead, replacement of both pulse generator and lead, or VNS removal surgery in the Maastricht UMC+. Multiple Imputation was used for missing data. Univariable and multivariable logistic regression analysis were performed to analyze possible risk factors, in case of a small sample size, an independent-samples Results: This study included a total of 606 VNS surgical procedures, leading to 67 complications of which 3 permanent complications. Complication rate after primary implantation was 13.4%; 2,5% for pulse generator replacement; 21.4% for lead revision and 27.3% for complete VNS removal. No statistically significant results were found when analyzing the results of adults and children <18 years separately. Discussion and conclusion: Complication rates of VNS-related surgeries in our own institutional series are low and comparable to previously reported series. VNS surgery is a relatively safe procedure. The complication rate differs per type of surgery and mean surgery duration was longer for patients with complications after lead revision surgery compared to patients without complications.
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