Evidence map›Paper›PMID 38510504›Full record

ArticleAmerican heart journal plus : cardiology research and practice2024

Myocardial perfusion imaging-derived left ventricular strain: Regional abnormalities associated with transthyretin cardiac amyloidosis.

Steven Lewis, Jingwen Huang, Nidhi Patel, Russell Folks, James Galt, C David Cooke, Ziduo Zheng, Rebecca Zhang, Ernest Garcia, Jonathon Nye and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American heart journal plus : cardiology research and practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Steven LewisDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Jingwen HuangDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Nidhi PatelDepartment of Medicine, Emory University School of Medicine, Atlanta, GA, USA.
Russell FolksDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
James GaltDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
C David CookeDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Ziduo ZhengDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health at Emory University, Atlanta, GA, USA.
Rebecca ZhangDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health at Emory University, Atlanta, GA, USA.
Ernest GarciaDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Jonathon NyeDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Marina PiccinelliDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Valeria MoncayoDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Kunal BhattDepartment of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
Adam MitchellDepartment of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA.
Emory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Transthyretin (ATTR) cardiac amyloidosis is associated with an apical-sparing strain pattern on TTE. We hypothesize that strain indices derived from myocardial perfusion imaging (MPI) can identify this abnormality. Methods: A group with ATTR amyloidosis was compared to age-matched controls with LVH but without amyloidosis who underwent PET or SPECT MPI. Strain values were used to calculate the apical strain index (ASI), apex-to-base ratio (ABR), and ejection fraction to global strain ratio in multiple planes. Results: A direct comparison using Welch's Conclusion: MPI-derived strain from the circumferential plane at rest may distinguish cardiac amyloidosis from other forms of LVH. If these findings are confirmed with validation studies, routine MPI-derived strain analysis could identify patients with subclinical amyloidosis who may benefit from further testing.

Indexed as

ATTR amyloidosisMyocardial perfusion imagingMyocardial strain

Identifiers

PMID38510504
PMCPMC10945994
OpenAlexW4392303428

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.