Evidence map›Paper›PMID 38510264›Full record

ReviewDigital biomarkers

Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age.

Walter Maetzler, Leonor Correia Guedes, Kirsten Nele Emmert, Jennifer Kudelka, Hanna Luise Hildesheim, Emma Paulides, Hayley Connolly, Kristen Davies, Valentina Dilda, Teemu Ahmaniemi and 26 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Digital biomarkers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Fatigue Among Adults Age 18 and Older: United States, 2024.National health statistics reports · 2026
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Walter MaetzlerDepartment of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Leonor Correia GuedesInstituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Kirsten Nele EmmertDepartment of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Jennifer KudelkaDepartment of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Hanna Luise HildesheimDepartment of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Emma PaulidesDepartment of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Hayley ConnollySchool of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland.
Kristen DaviesTranslational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK.
Valentina DildaCHDI Management, CHDI Foundation, Princeton, NJ, USA.
Teemu AhmaniemiTeknologian tutkimuskeskus VTT Oy, Espoo, Finland.
Luisa AvedanoEuropean Federation of Crohn's and Ulcerative Colitis, Brussels, Belgium.
Raquel Bouça-MachadoInstituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Michael ChambersMC Healthcare Evaluation, London, UK.
Meenakshi ChatterjeeJanssen Research and Development, Cambridge, MA, USA.
Peter GallagherTranslational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.
Johanna GraeberInstitute of General Medicine, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany.
Corina MaetzlerDepartment of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel and Kiel University, Kiel, Germany.
Hanna KaduszkiewiczInstitute of General Medicine, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany.
Norelee KennedySchool of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland.
Victoria MacraeTranslational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK.
Laura Carrasco MarinAsociación Parkinson Madrid, Madrid, Spain.
Anusha MosesSchool of Allied Health, Faculty of Education and Health Sciences and Health Research Institute, University of Limerick, Limerick, Ireland.
Alessandro PadovaniNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Andrea PilottoNeurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Natasha RatcliffeParkinson's UK, London, UK.
Ralf ReilmannGeorge-Huntington-Institute, R&D-Campus/Technology-Park Münster, Münster, Germany.
Madalena RosarioInstituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Stefan SchreiberDepartment of Internal Medicine I, University Medical Centre Schleswig-Holstein, Kiel University, Kiel, Germany.
Dina De SousaEuropean Huntington's Association, Moerbeke, Belgium.
Geert Van GassenMedical Department, Takeda, Brussels, Belgium.
Lori Ann WarringJanssen LLC, GCSO Immunology, Horsham, PA, USA.
Klaus SeppiDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
C Janneke van der WoudeDepartment of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Joaquim J FerreiraInstituto de Medicina Molecular João Lobo Antunes and Centro de Estudos Egas Moniz, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.
Wan-Fai NgTranslational and Clinical Research Institute, Newcastle University and NIHR Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK.
IDEA-FAST project consortium

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subjective and imprecise. With the recent advances of digital wearable technologies, novel approaches to evaluate daily function quantitatively and objectively in real-life conditions are increasingly possible. This also creates new possibilities to measure fatigue-related changes of daily function using such technologies. Summary: This review examines which digitally assessable parameters in immune-mediated inflammatory and neurodegenerative diseases may have the greatest potential to reflect fatigue-related changes of daily function. Key Messages: Results of a standardized analysis of the literature reporting about perception-, capacity-, and performance-evaluating assessment tools indicate that changes of the following parameters: physical activity, independence of daily living, social participation, working life, mental status, cognitive and aerobic capacity, and supervised and unsupervised mobility performance have the highest potential to reflect fatigue-related changes of daily function. These parameters thus hold the greatest potential for quantitatively measuring fatigue in representative diseases in real-life conditions, e.g., with digital wearable technologies. Furthermore, to the best of our knowledge, this is a new approach to analysing evidence for the design of performance-based digital assessment protocols in human research, which may stimulate further systematic research in this area.

Indexed as

Activities of daily lifeInternational Classification of Functioning, disability and healthPerformanceWearables

Identifiers

PMID38510264
PMCPMC10954320

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.